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Keywords: RhoGEF
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Journal Articles
Journal: Development
Development (2021) 148 (11): dev199232.
Published: 14 June 2021
... individual organisms ( Chanet et al., 2017 ; Hong et al., 2016 ; von Dassow and Davidson, 2009 ). Actomyosin Morphogenesis RhoGAP RhoGEF Tissue folding Transcriptional patterning Drosophila cDNA was generated from extracted mRNA with the Invitrogen SuperScript™ III First-Strand...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev168922.
Published: 12 December 2018
... is not shared by arhgef3 , which encodes another organizer-specific RhoGEF. Plekhg5 protein is localized in the apical cell cortex via its pleckstrin homology domain, and the GEF activity enhances its apical recruitment. Plekhg5 induces apical actomyosin accumulation and cell elongation. Knockdown of plekhg5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4937–4946.
Published: 15 December 2013
... discovered a new mechanism for regulating the Wnt pathway: activity of a Rho guanine nucleotide exchange factor (GEF) encoded by pebble ( pbl ) in Drosophila and ECT2 in humans. This RhoGEF has an essential role in cytokinesis, but also plays an unexpected, conserved role in inhibiting Wg/Wnt activity. Loss...
Journal Articles
Journal: Development
Development (2011) 138 (23): 5177–5188.
Published: 01 December 2011
... invagination. * Author for correspondence ( Richard.Lang@cchmc.org ) Competing interests statement The authors declare no competing financial interests. 27 9 2011 © 2011. Apical constriction Invagination Rho GTPases RhoGEF Shroom Mouse Chick...
Journal Articles
Journal: Development
Development (2005) 132 (18): 4165–4178.
Published: 15 September 2005
... shown to activate Rho signaling ( Wettschureck and Offermanns, 2002 ) and one particularly important pathway of Rho activation is through guanine nucleotide exchange factors (RhoGEFS), which catalyze the exchange of GDP for GTP on Rho GTPases, thus activating them. Signaling from Rho through...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (11): 2631–2640.
Published: 01 June 2004
... for correspondence (e-mail: muellear@uni-duesseldorf.de ) 28 2 2004 © 2004. 2004 Drosophila Cell migration Gastrulation FGF-receptor RhoGEF The spatiotemporal pattern of cell migration in the embryo is crucial for cells to receive and send out signals essential for correct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (11): 2641–2651.
Published: 01 June 2004
... to their neighbours and extend very few protrusions. Consistent with the dependence of the mesoderm EMT and cytokinesis on actin organisation, the GTP exchange function of the PBL RhoGEF is required for both processes. By contrast, the N-terminal BRCT domains of PBL are required only for the cytokinetic function...
Journal Articles
Journal: Development
Development (2002) 129 (5): 1215–1223.
Published: 01 March 2002
...@bio.nagoya-u.ac.jp ) 12 12 2001 © 2002. 2002 Rho-kinase MBS zipper spaghetti-squash Rho RhoGEF Morphogenesis Drosophila melanogaster Morphogenesis is a complex set of processes in which a number of cellular functions such as signal transduction, cell movements...