..., the expression of LSox5 is maintained in cephalic crest derivatives, and it appears to be required for the development of the glial lineage, the Schwann cells and satellite glia in cranial ganglia. Misexpression of LSox5 in the cephalic neural tube activated RhoB expression throughout the dorsoventral axis...

... that Slug can induce the expression of rhoB and an increase in the number of HNK-1-positive migratory cells, indicating that it lies upstream of them in the genetic cascade of neural crest development. The increase in neural crest production after Slug overexpression was confined to the cranial region...

... © 2000 by Company of Biologists 2000 Avian embryo BMP Cadherin Cell delamination Dermomyotome Epithelial-mesenchymal conversion RhoB Slug TGFβ The neural crest (NC) arises in the lateral tips of the neural folds that become the dorsal midline upon formation of the neural tube...

... in vivo was preceded by a partial or total reduction in the expression of cadherin-6B and rhoB but not in the expression of slug mRNA or protein. Altogether, these results suggest that a coordinated activity of Noggin and BMP4 in the dorsal neural tube triggers delamination of specified, slug -expressing...