... show that Combover (Cmb), originally identified as an effector of planar cell polarity (PCP) under control of Rho kinase, is essential for sperm individualization. cmb mutants are male sterile, with actin cones that fail to move in a synchronized manner along the flagella, despite being correctly...

... Highlighted article : A new method for measuring tissue-scale force production is used to investigate the mechanical control of convergent extension in Xenopus embryos. Morphogenesis Mechanotransduction Gastrulation Notochord Cell and tissue mechanics Rho Kinase Viscoelasticity...

... role of JNK in this context has remained elusive. Here, we show that JNK activity is indispensable for the rearrangement of endoderm cells that underlies the elongation of the Xenopus gut tube. Whereas Rho kinase is necessary to induce cell intercalation and remodel adhesive contacts, we have found...

.... Using gain- and loss-of-function experiments, we demonstrate that Shroom3 is the main organizer of cell shape changes during rosette assembly, probably by coordinating Rho kinase recruitment and non-muscle myosin activation. In order to quantify morphogenesis in the LL primordium in an unbiased manner...

... and spatial precision. To this end, we have developed a novel pharmacological agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activity in vivo. A new photolabile caging group, 6-nitropiperonyloxymethyl (NPOM), was installed on a small-molecule inhibitor of Rho...

... along the AP axis, with more ciliated cells densely packed into the anterior region. Here, we identify a Rho kinase gene, rock2b , which is required for normal AP patterning of KV and subsequent LR development in the embryo. Antisense depletion of rock2b in the whole embryo or specifically in the KV...

... for correspondence( lmichel@igbmc.fr ) * Present address: Molecular, Cell and Developmental Biology, UCSC, Santa Cruz, CA 95064, USA 13 7 2009 © 2009. © 2009. 2009 Actin Non-muscle myosin II Morphogenesis Phosphorylation Rho kinase C. elegans Morphogenesis is an essential...

...., Kimura, K., Fukata, Y., Chihara, K., Nakano,T., Matsuura, Y. and Kaibuchi, K. ( 1996 ). Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271 , 20246 -20249. Barrett, K., Leptin, M. and Settleman, J. ( 1997 ). The Rho GTPase and a putative RhoGEF...

... 2004 © 2004. 2004 Cytokinesis Citron Kinase Rho Kinase Drosophila Rho GTPase signalling Pebble Rho GEF Cytokinesis is the final step in the cell division cycle when two prospective daughter cells are separated by ingression of the plasma membrane between separating...

... is necessary for cell movement, but strong adhesion inhibits cell movement. * Author for correspondence (e-mail: perrimon@rascal.med.harvard.edu ) 21 11 2002 © 2003. 2003 Rac Rho Rho kinase Myosin II Myosin phosphatase zipper spaghetti-squash MYPT Dorsal closure Ring...

...Lei Wei; Wilmer Roberts; Lu Wang; Miho Yamada; Shuxing Zhang; Zhiyong Zhao; Scott A. Rivkees; Robert J. Schwartz; Kyoko Imanaka-Yoshida Rho-associated kinases (Rho kinases), which are downstream effectors of RhoA GTPase, regulate diverse cellular functions including actin cytoskeletal organization...