... is differentially regulated in ICM and TE cells is poorly understood. Through an inhibitor/activator screen, we have identified Rho as a negative regulator of Hippo in TE cells, and PKA as a positive regulator of Hippo in ICM cells. We further elucidated a novel mechanism by which Rho suppresses Hippo, distinct...

... differentiation requires dynamic interactions with somatic escort cells. This involves a complex meshwork of escort cell protrusions and is regulated by multiple signalling pathways. Germline stem cells Escort cells Drosophila Stat Erk Rho Cdc42 Protrusion Balancing stem cell maintenance...

... kidney, can be used for examining mechanisms of renal progenitor differentiation. 24 10 2005 © 2006. 2006 Progenitor Kidney Colony-forming assay Sall1 Wnt PCP JNK Rho Mouse Mammalian adult kidney, metanephros, is formed by reciprocally inductive...

... is required for cytokinesis in every tissue examined, with mutant cells exhibiting multinucleate and hyperploid phenotypes. Strong genetic interactions were observed between citron and pbl alleles and constructs. Vertebrate studies implicate at least two Rho effector kinases, Citron and Rok, in cytokinesis...

...Masha Smallhorn; Michael J. Murray; Robert Saint Drosophila pebble ( pbl ) encodes a Rho-family GTP exchange factor (GEF) required for cytokinesis. The accumulation of high levels of PBL protein during interphase and the developmentally regulated expression of pbl in mesodermal tissues suggested...

... in exploring the extracellular surroundings with filopodia-like Actin containing projections. We hypothesized that the small GTPases Rho, Rac and Cdc42 are involved in Actin cytoskeletal rearrangements that underlie peripheral glial migration and nerve ensheathement. To test this, transgenic forms...

... is necessary for cell movement, but strong adhesion inhibits cell movement. * Author for correspondence (e-mail: perrimon@rascal.med.harvard.edu ) 21 11 2002 © 2003. 2003 Rac Rho Rho kinase Myosin II Myosin phosphatase zipper spaghetti-squash MYPT Dorsal closure Ring...

... cell shape change. Aberrant accumulation of F-actin within the leading edge cells may correspond to the morphological aberrations of such cells. Similar defects were seen in embryos overexpressing Rho-kinase, suggesting that myosin phosphatase and Rho-kinase function antagonistically. The genetic...

...Doris Brentrup; Hans-Philipp Lerch; Herbert Jäckle; Markus Noll ABSTRACT The stereotyped pattern of veins in the Drosophila wing is generated in response to local EGF signalling. Mutations in the rhomboid ( rho ) gene, which encodes a sevenpass membrane protein required to enhance signalling...

... Jones Bridge Road, Bethesda MD 20814-4799, USA § Author for correspondence (e-mail: mlodzik@embl-heidelberg.de ) 27 01 2000 © 2000 by Company of Biologists 2000 RasGAP Development Ommatidial polarity Ras Rho Drosophila The understanding of the molecular...

... binds to actin in the interaction trap system and in vitro. In addition, SPIRE interacts with the rho family GTPases RHOA, RAC1 and CDC42 in the interaction trap system. Thus, our evidence supports the model that SPIRE links rho family signaling to the actin cytoskeleton. * Author...

...Katrin Wünnenberg-Stapleton; Ira L. Blitz; Chikara Hashimoto; Ken W. Y. Cho The Rho family of small GTPases regulates a variety of cellular functions, including the dynamics of the actin cytoskeleton, cell adhesion, transcription, cell growth and membrane trafficking. We have isolated the first...

... of neural crest differentiation, we performed a PCR-based screen for genes induced by BMPs in chick neural plate cells. We describe the cloning and characterization of one gene obtained from this screen, rhoB , a member of the rho family GTP-binding proteins. rhoB is expressed in the dorsal neural tube...