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Keywords: Rhabdomyosarcoma
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Journal Articles
Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis
Available to PurchaseNarie Y. Storer, Richard M. White, Audrey Uong, Emily Price, G. Petur Nielsen, David M. Langenau, Leonard I. Zon
Journal:
Development
Development (2013) 140 (14): 3040–3050.
Published: 15 July 2013
...Narie Y. Storer; Richard M. White; Audrey Uong; Emily Price; G. Petur Nielsen; David M. Langenau; Leonard I. Zon Rhabdomyosarcoma is a pediatric malignancy thought to arise from the uncontrolled proliferation of myogenic cells. Here, we have generated models of rhabdomyosarcoma in the zebrafish...
Includes: Supplementary data
Journal Articles
A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development
Available to PurchaseXiuning Le, Emily K. Pugach, Simone Hettmer, Narie Y. Storer, Jianing Liu, Airon A. Wills, Antony DiBiase, Eleanor Y. Chen, Myron S. Ignatius, Kenneth D. Poss, Amy J. Wagers, David M. Langenau, Leonard I. Zon
Journal:
Development
Development (2013) 140 (11): 2354–2364.
Published: 1 June 2013
... was activated by RAS, and this was used as the basis for a chemical genetic screen to identify small molecules that interfere with RAS signaling during embryogenesis. A KRAS G12D -induced zebrafish embryonal rhabdomyosarcoma was then used to assess the therapeutic effects of the small molecules. Two...
Includes: Supplementary data
