... is important in neurons. Here, we tested the role of Tctp in retinal axon development in Xenopus laevis . We report that Tctp deficiency results in stunted and splayed retinotectal projections that fail to innervate the optic tectum at the normal developmental time owing to impaired axon extension. Tctp...

[email protected] ; [email protected] ) 19 4 2006 © 2006. 2006 Axon guidance Microcontact printing Retinotectal projection Chick Axonal pathfinding plays an important role in the development of the complex connectivity of the nervous system. The correct navigation of axons...

... growth cones,which is required for topographic map formation. * Author for correspondence (e-mail: [email protected] ) 29 10 2004 ©2005. 2005 Retinotectal projection Topographic mapping Fasciculation Axon branching Visual system Zebrafish For an animal to see well...

... ). * Author for correspondence e-mail: ( [email protected] ) 11 7 2003 © 2003. 2003 Retina Chick Retinotectal projection CBF1 BMP2 Although ephrin A5 and ephrin A2 are also known to be expressed in nasal high/temporal low gradients ( Cheng and Flanagan, 1994 ), their spatial...

...-A5-Fc, as only 2 out of 12 growth cones showed a growth cone collapse, while the growth direction of the other 10 was unaffected( Fig. 4 ). * Author for correspondence (e-mail: [email protected] ) 13 1 2003 © 2003. 2003 Axon guidance Retinotectal projection Ephrin-A5...

...-mail: [email protected] ) 22 10 2002 © 2003. 2003 groucho En Cell fate Lamination Retinotectal projection Remodeling Most neurons that make up the vertebrate nervous system arise from the ventricular layer. After proliferating in the ventricular layer, postmitotic...

...Dorothea Schulte; Constance L. Cepko ABSTRACT Graded expression of the Eph receptor EphA3 in the retina and its two ligands, ephrin A2 and ephrin A5 in the optic tectum, the primary target of retinal axons, have been implicated in the formation of the retinotectal projection map. Two homeobox...

... the retinotectal projection along the DV axis, as the mfp graft did. These results suggest that some factors from the mesencephalic floor plate or the tegmentum, or Shh itself, play a crucial role in the establishment of the DV polarity of the tectum and the retinotectal projection map along the DV axis...

... organ, the tectum, in a highly ordered fashion. We performed a large-scale screen for mutations affecting the retinotectal projection of the zebrafish, which resulted in the identification of 114 mutations. 44 of these mutations disturb either the order of RGC axons in the optic nerve and tract...

... receptors choline acetyltransferase neurotransmitter optic tectum retinal ganglion cells retinotectal projection substance P chick Finally, we used antisera to SP receptors and ChAT to label putative targets of the SPand AChR-positive RGCs. No previous reports on the structure or distribution...

... expression was repressed, and vice versa . Next we studied the correlation between engrailed expression and retinotectal projection from a view of plasticity and rigidity of rostrocaudal polarity in the tectum. We produced ectopic tecta by anisochronal transplantations between E3 host and E2 donor...

...Hiroyuki Ichijo; Setsuya Fujita; Toru Matsuno; Harukazu Nakamura ABSTRACT Retinotectal projection is precisely organized in a retinotopic manner. In normal projection, temporal retinal axons project to the rostral part of the tectum, and nasal axons to the caudal part of the tectum. The two...

... retinotectal projection One approach used to investigate the mechanisms by which optic nerve fibres form orderly connections has been to examine the relative order among nerve fibres in the optic pathways ( Bunt & Horder, 1983 ; Walsh & Guillery, 1984 ; Easter, 1985 ). For this approach...

... of tetrodotoxin (TTX), during the regeneration of the optic nerve in goldfish has been found to prevent the re-emergence of a fully ordered retinotectal projection. We sought to determine the effects of visual deprivation, a less radical perturbation of neural activity than that produced by TTX, on the initial...