... hormone-dependent metamorphic pathways in the self-correction of abnormal craniofacial morphology. In wild-type tadpoles, thyroid hormone receptor α ( thrα ) and retinoid X receptor α ( rxrα ) gene expression increases at pre-metamorphic stages and their gene products form heterodimers that repress...

... between these processes would result in a variety of congenital cardiac defects such as those seen in the retinoid X receptor α knockout ( Rxra –/– ) mouse. Rxra –/– embryos exhibit lethality between embryonic day (E) 13.5 and 15.5 and harbor a variety of conotruncal and aortic sac defects making...

...Anthony E. Oro; Michael Mckeown; Ronald M. Evans ultraspiracle (usp) encodes the Drosophila cognate of RXR, the human retinoid X receptor. To examine how RXR subfamily members function in development, we have undertaken a phenotypic analysis of usp mutants. usp is required at multiple stages...