..., which both express RA-synthesizing retinaldehyde dehydrogenases (RALDH1 and RALDH3), but the neural crest cell-derived periocular mesenchyme (POM), which is devoid of RALDH. In POM, the effects of the paracrine RA signal are mediated by the nuclear RA receptors heterodimers RXRα/RARβ and RXRα/RARγ...

... affects limb morphogenesis in mutant mouse embryos deficient for the retinaldehyde dehydrogenase 2 (Raldh2/Aldh1a2). These mutants, which have no detectable embryonic RA except in the developing retina, die at E9.5-E10 without any evidence of limb bud formation, but maternal RA supplementation through...

... ). Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway. Neuron 21 , 39 -51. Grün, F., Hirose, Y., Kawauchi, S., Ogura, T. and Umesono, K. ( 2000 ). Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory...

... established in a mammalian system. To block endogenous RA synthesis, we have disrupted the gene encoding RALDH2, the first retinaldehyde dehydrogenase whose expression has been detected during early mouse post-implantation development. We describe here the heart abnormalities of the RA-deficient Raldh2...

[email protected] ) 15 01 2001 13 03 2001 © 2001 by Company of Biologists 2001 Cardiomyocyte differentiation Heart development Left-right patterning Mouse mutant Myocardium Raldh2 Retinaldehyde dehydrogenase Retinoids Tbx5 One of the primary patterning decisions required...

...Karen Niederreither; Julien Vermot; Brigitte Schuhbaur; Pierre Chambon; Pascal Dollé ABSTRACT Targeted disruption of the murine retinaldehyde dehydrogenase 2 ( Raldh2 ) gene precludes embryonic retinoic acid (RA) synthesis, leading to midgestational lethality (Niederreither, K., Subbarayan, V...