... mechanisms of eye size control remain poorly understood. Here, we discovered that the lipogenic transcription factor sterol regulatory element-binding protein 2 (SREBP2) has an unanticipated function in the retinal pigment epithelium (RPE) to promote eye size in postnatal mice. SREBP2 transcriptionally...

...Lena Iwai-Takekoshi; Revathi Balasubramanian; Austen Sitko; Rehnuma Khan; Samuel Weinreb; Kiera Robinson; Carol Mason ABSTRACT In mammalian albinism, disrupted melanogenesis in the retinal pigment epithelium (RPE) is associated with fewer retinal ganglion cells (RGCs) projecting ipsilaterally...

...Kapil Bharti; Wenfang Liu; Tamas Csermely; Stefano Bertuzzi; Heinz Arnheiter During vertebrate eye development, the transcription factor MITF plays central roles in neuroepithelial domain specification and differentiation of the retinal pigment epithelium. MITF is not a single protein...

...Frank Müller; Hermann Rohrer; Astrid Vogel-Höpker In vertebrates, the neuroepithelium of the optic vesicle is initially multipotential, co-expressing a number of transcription factors that are involved in retinal pigment epithelium (RPE) and neural retina (NR)development. Subsequently, extrinsic...

... as the optic vesicle and optic cup mature. We show that two other Hedgehog proteins, Banded hedgehog and Cephalic hedgehog,related to the mouse Indian hedgehog and Desert hedgehog, respectively, are strongly expressed in the central retinal pigment epithelium but excluded from the peripheral pigment epithelium...

... and the retinal pigment epithelium in the eye. The molecular mechanisms that pattern neural and non-neural tissues within the neuroectoderm remain unknown. We report that FGF9 is normally expressed in the distal region of the optic vesicle that is destined to become the neural retina, suggesting a role in neural...

.... * Author for correspondence (e-mail: [email protected] ) 27 05 2000 20 07 2000 © 2000 by Company of Biologists 2000 Retinal pigment epithelium Neuroretina Neuroepithelium Optic vesicle culture Transcription factor Transcriptional repression Mouse Cell-fate specification...

... of disorganization of its layers. These RARβ2γ2 mutants represent the first genetically characterized model of retinal dysplasia and their phenotype demonstrates that RARs, and therefore RA, are required for retinal histogenesis. The RARβ2γ2 retinal pigment epithelium (RPE) cells display histological...

...Günter H. Schmidt; Maureen M. Wilkinson; Bruce A. J. Ponder ABSTRACT Clonal analysis of whole-mount preparations of entire retinal pigment epithelium (RPE), using SWR↔C57BL/6JLac and DDK↔C3H/Bi mouse aggregation chimaeras in which one of the two parental components predominated, revealed a markedly...