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Keywords: Retinal ganglion cells
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Journal Articles
Journal: Development
Development (2020) 147 (23): dev196535.
Published: 07 December 2020
...Shane D'Souza; Richard A. Lang ABSTRACT Retinal ganglion cells (RGCs) serve as a crucial communication channel from the retina to the brain. In the adult, these cells receive input from defined sets of presynaptic partners and communicate with postsynaptic brain regions to convey features of the...
Journal Articles
Journal: Development
Development (2013) 140 (3): 541–551.
Published: 01 February 2013
... the expression of a particular bHLH factor influences RPC fate is unclear. Previously, we have shown that Neurod1 inserted into the Atoh7 locus activates the retinal ganglion cell (RGC) program in Atoh7 -expressing RPCs but not in Neurod1 -expressing RPCs, suggesting that Atoh7 -expressing RPCs are...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (22): 3767–3777.
Published: 15 November 2009
... typically have two distinct cones, whereas four cones persist in birds. Consequently, the postsynaptic wiring is expected to be more complex in birds and the far more elaborate dendritic arbors of chicken retinal ganglion cells(RGCs) compared with mouse RGCs might reflect such an increased complexity of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3379–3388.
Published: 15 October 2008
... establishing retinal ganglion cell (RGC) fate. We analyzed the retinas of mice in which Math5 was replaced with Neurod1 or Math3 , bHLH genes that are expressed in another RPC and are required to establish amacrine cell fate. In the absence of Math5, Math5 Neurod1-KI was able to specify RGCs, activate RGC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 271–280.
Published: 15 January 2008
...Chai-An Mao; Takae Kiyama; Ping Pan; Yasuhide Furuta; Anna-Katerina Hadjantonakis; William H. Klein The mechanisms regulating retinal ganglion cell (RGC) development are crucial for retinogenesis and for the establishment of normal vision. However,these mechanisms are only vaguely understood. RGCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (11): 2201–2210.
Published: 01 June 2006
... ganglion cell genesis. Conversely, absorbing endogenous VEGF ligand or disrupting FLK1 activity attenuates cell proliferation and enhances retinal ganglion cell production. In addition, we provide evidence that VEGF signals transmitted by the FLK1 receptor activate divergent intracellular signaling...
Journal Articles
Journal: Development
Development (2005) 132 (4): 703–712.
Published: 15 February 2005
..., Brn3a ki functionally restored the normal development and survival of retinal ganglion cells (RGCs) in the absence of Brn3b and fully reinstated the early developmental expression profiles of Brn3b downstream target genes in retina. These results indicate that Brn3 factors are functionally equal and...
Journal Articles
Journal: Development
Development (2003) 130 (13): 2967–2980.
Published: 01 July 2003
... hedgehog (Shh) from retinal ganglion cells (RGCs) promotes the development of optic disc and stalk neuroepithelial cells. We demonstrate that RGCs express Shh soon after differentiation, and cells at the optic disc in close proximity to the Shh-expressing RGCs upregulate Hh target genes, which suggests...
Journal Articles
Journal: Development
Development (2001) 128 (20): 3927–3936.
Published: 15 October 2001
...Françoise Trousse; Elisa Martí; Peter Gruss; Miguel Torres; Paola Bovolenta Retinal ganglion cell (RGC) axons grow towards the diencephalic ventral midline during embryogenesis guided by cues whose nature is largely unknown. We provide in vitro and in vivo evidence for a novel role of Sonic...