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Keywords: Retina
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (17): dev200610.
Published: 13 September 2022
...-type versus adenomatosis polyposis coli downregulated 1 ( Apcdd1 −/− ) mouse retinas revealed that Lama2 mRNA and protein levels are increased in mutant vasculature with higher Wnt/β-catenin signaling. Mural cells are the main source of Lama2, and Wnt/β-catenin activation induces Lama2 expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (15): dev200642.
Published: 8 August 2022
... in the adult mouse and human retina, including a conserved region nearby Prdm1 , a factor implicated in the specification of rod photoreceptors and suppression of bipolar cell fate. VSX2 interacts with the transcription factor OTX2 and can act to suppress OTX2-dependent enhancer transactivation of the Prdm1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200569.
Published: 16 June 2022
.... and Bishop , P. N. ( 2018 ). Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice . Mol. Ther. Method. Clin. Dev. 9 , 192 - 202 . 10.1016/j.omtm.2017.12.002 Chuang , J. Z. , Hsu , Y. C. and Sung , C. H...
Journal Articles
Journal: Development
Development (2022) 149 (6): dev195644.
Published: 14 March 2022
... and disrupted retinal cell proliferation and differentiation. Retinal ganglion cells were overproduced in Uhrf2 -deficient retinae at the expense of VSX2 + RPCs. Most other cell types were transiently delayed in differentiation. Expression of each member of the Tet3 / Uhrf2 / Tdg active demethylation pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (5): dev200127.
Published: 4 March 2022
...Warren A. Campbell; Allen Tangeman; Heithem M. El-Hodiri; Evan C. Hawthorn; Maddie Hathoot; Sydney Blum; Thanh Hoang; Seth Blackshaw; Andy J. Fischer ABSTRACT A recent comparative transcriptomic study of Müller glia (MG) in vertebrate retinas revealed that fatty acid binding proteins (FABPs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199634.
Published: 24 January 2022
... along the margin of the Drosophila eye prevents the initiation of pattern formation, indicating that the timing of cell fate decisions is vital for successful eye development. Eyes absent Eye-antennal disc Morphogenetic furrow Drosophila Retina Cell fate National Eye Institute...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev192047.
Published: 20 January 2022
...Françoise Helmbacher ABSTRACT Angiogenesis is a stepwise process leading to blood vessel formation. In the vertebrate retina, endothelial cells are guided by astrocytes migrating along the inner surface, and the two processes are coupled by a tightly regulated cross-talks between the two cell types...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199484.
Published: 17 January 2022
...Huanqing Zhang; Pei Zhuang; Ryan M. Welchko; Manhong Dai; Fan Meng; David L. Turner ABSTRACT The mammalian retina contains a complex mixture of different types of neurons. We find that microRNA miR-216b is preferentially expressed in postmitotic retinal amacrine cells in the mouse retina...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2021) 148 (9): dev199418.
Published: 7 May 2021
...Robin M. Perelli; Matthew L. O'Sullivan; Samantha Zarnick; Jeremy N. Kay ABSTRACT Angiogenesis in the developing mammalian retina requires patterning cues from astrocytes. Developmental disorders of retinal vasculature, such as retinopathy of prematurity (ROP), involve arrest or mispatterning...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev198549.
Published: 30 April 2021
...Nicolas Lonfat; Su Wang; ChangHee Lee; Mauricio Garcia; Jiho Choi; Peter J. Park; Connie Cepko ABSTRACT The vertebrate retina is generated by retinal progenitor cells (RPCs), which produce >100 cell types. Although some RPCs produce many cell types, other RPCs produce restricted types...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (23): dev196535.
Published: 7 December 2020
...Shane D'Souza; Richard A. Lang ABSTRACT Retinal ganglion cells (RGCs) serve as a crucial communication channel from the retina to the brain. In the adult, these cells receive input from defined sets of presynaptic partners and communicate with postsynaptic brain regions to convey features...
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192500.
Published: 23 November 2020
... principles. We report that inter-species blastula transplantations result in the ectopic formation of a retina formed by donor cells – a module. We show that the time taken for the retina to develop follows a genetic program: an ectopic zebrafish retina in medaka develops with zebrafish dynamics...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev182923.
Published: 13 October 2020
.... and Norden , C. ( 2018 ). Neuronal migration and lamination in the vertebrate retina . Front. Neurosci.   11 , 742 . 10.3389/fnins.2017.00742 Arendt , D. , Tessmar , K. , de Campos-Baptista , M. I. M. , Dorresteijn , A. and Wittbrodt , J. ( 2002 ). Development of pigment...
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188730.
Published: 28 September 2020
... genesis and, given their widespread expression in the nervous system, raise the possibility of a general role in temporal patterning. This article has an associated ‘ The people behind the papers ’ interview. Next, we asked whether POU2F1 and POUF2 are also expressed in the developing human retina. Our...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev190272.
Published: 3 July 2020
...Noah B. Goodson; Michael A. Kaufman; Ko U. Park; Joseph A. Brzezinski, IV ABSTRACT The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers. PRDM1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183418.
Published: 22 May 2020
... into neurogenic progenitors is key to harnessing the regenerative potential of the retina . Inflammation and reactive microglia are known to influence the formation of Müller glia-derived progenitor cells (MGPCs), but the mechanisms underlying this interaction are unknown. We used a chick in vivo model...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2019) 146 (20): dev174409.
Published: 17 October 2019
...Yu Gong; Xiangyu He; Qiyou Li; Juncai He; Baishijiao Bian; Yijian Li; Linlin Ge; Yuxiao Zeng; Haiwei Xu; Zheng Qin Yin ABSTRACT The stem cell factor receptor (SCFR) has been demonstrated to be expressed in the neural retina of mice, rat and human for decades. Previous reports indicated...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (17): dev179556.
Published: 2 September 2019
...Stefanie G. Wohl; Marcus J. Hooper; Thomas A. Reh ABSTRACT Müller glial cells (MG) generate retinal progenitor (RPC)-like cells after injury in non-mammalian species, although this does not occur in the mammalian retina. Studies have profiled gene expression in these cells to define genes that may...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev178012.
Published: 4 July 2019
.... ( 2017 ). Molecular anatomy of the developing human retina . Dev. Cell   43 , 763 - 779.e764 . 10.1016/j.devcel.2017.10.029 Huang , J. , Dibble , C. C. , Matsuzaki , M. and Manning , B. D. ( 2008 ). The TSC1-TSC2 complex is required for proper activation of mTOR complex 2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173450.
Published: 24 May 2019
...Rana Amini; Anastasia A. Labudina; Caren Norden; Allon Klein; Barbara Treutlein ABSTRACT Developmental programs that arrange cells and tissues into patterned organs are remarkably robust. In the developing vertebrate retina, for example, neurons reproducibly assemble into distinct layers giving...
Includes: Supplementary data