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Keywords: Retina
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev199418.
Published: 07 May 2021
...Robin M. Perelli; Matthew L. O'Sullivan; Samantha Zarnick; Jeremy N. Kay ABSTRACT Angiogenesis in the developing mammalian retina requires patterning cues from astrocytes. Developmental disorders of retinal vasculature, such as retinopathy of prematurity (ROP), involve arrest or mispatterning...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev198549.
Published: 30 April 2021
...Nicolas Lonfat; Su Wang; ChangHee Lee; Mauricio Garcia; Jiho Choi; Peter J. Park; Connie Cepko ABSTRACT The vertebrate retina is generated by retinal progenitor cells (RPCs), which produce >100 cell types. Although some RPCs produce many cell types, other RPCs produce restricted types...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev196535.
Published: 07 December 2020
...Shane D'Souza; Richard A. Lang ABSTRACT Retinal ganglion cells (RGCs) serve as a crucial communication channel from the retina to the brain. In the adult, these cells receive input from defined sets of presynaptic partners and communicate with postsynaptic brain regions to convey features...
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192500.
Published: 23 November 2020
... principles. We report that inter-species blastula transplantations result in the ectopic formation of a retina formed by donor cells – a module. We show that the time taken for the retina to develop follows a genetic program: an ectopic zebrafish retina in medaka develops with zebrafish dynamics...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev182923.
Published: 13 October 2020
.... ( 2018 ). Neuronal migration and lamination in the vertebrate retina . Front. Neurosci.   11 , 742 . 10.3389/fnins.2017.00742 Arendt , D. , Tessmar , K. , de Campos-Baptista , M. I. M. , Dorresteijn , A. and Wittbrodt , J. ( 2002 ). Development of pigment-cup eyes...
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188730.
Published: 28 September 2020
... the rod-promoting factor Nrl to control the timing of cone genesis in the mouse retina. Cell fate Mouse Photoreceptors Retina Temporal patterning Transcription The generation of neuronal diversity is crucial to building a functional nervous system. Classical studies have shown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev190272.
Published: 03 July 2020
...Noah B. Goodson; Michael A. Kaufman; Ko U. Park; Joseph A. Brzezinski, IV ABSTRACT The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers. PRDM1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183418.
Published: 22 May 2020
... into neurogenic progenitors is key to harnessing the regenerative potential of the retina . Inflammation and reactive microglia are known to influence the formation of Müller glia-derived progenitor cells (MGPCs), but the mechanisms underlying this interaction are unknown. We used a chick in vivo model...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2019) 146 (20): dev174409.
Published: 17 October 2019
...Yu Gong; Xiangyu He; Qiyou Li; Juncai He; Baishijiao Bian; Yijian Li; Linlin Ge; Yuxiao Zeng; Haiwei Xu; Zheng Qin Yin ABSTRACT The stem cell factor receptor (SCFR) has been demonstrated to be expressed in the neural retina of mice, rat and human for decades. Previous reports indicated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179556.
Published: 02 September 2019
...Stefanie G. Wohl; Marcus J. Hooper; Thomas A. Reh ABSTRACT Müller glial cells (MG) generate retinal progenitor (RPC)-like cells after injury in non-mammalian species, although this does not occur in the mammalian retina. Studies have profiled gene expression in these cells to define genes that may...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev178012.
Published: 04 July 2019
... neurons, which die in glaucoma leading to irreversible vision loss. Regeneration Retina mTOR Development RGC Glaucoma Axons regenerate poorly in the central nervous system (CNS), leading to functional deficits, often permanent, following brain disease or injury ( Curcio and Bradke, 2018...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173450.
Published: 24 May 2019
...Rana Amini; Anastasia A. Labudina; Caren Norden; Allon Klein; Barbara Treutlein ABSTRACT Developmental programs that arrange cells and tissues into patterned organs are remarkably robust. In the developing vertebrate retina, for example, neurons reproducibly assemble into distinct layers giving...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (1): dev171686.
Published: 09 January 2019
.... Zack; Melissa C. Skala; David M. Gamm ABSTRACT Numerous protocols have been described for producing neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids. Although nearly all such methods yield at least partial segments of retinal structure...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163329.
Published: 02 August 2018
...Luke R. Baker; Bonnie M. Weasner; Athena Nagel; Sarah D. Neuman; Arash Bashirullah; Justin P. Kumar ABSTRACT The transcription factor Pax6 is considered the master control gene for eye formation because (1) it is present within the genomes and retina/lens of all animals with a visual system; (2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev159970.
Published: 30 April 2018
... is necessary for their expression, although overexpression of Lhx2 / Ldb1 does not elevate expression of these proneural bHLH factors. Finally, we demonstrate that the relative level of the LHX2-LDB1 complex in the retina decreases in tandem with the onset of gliogenesis. These findings show that control...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev157511.
Published: 25 April 2018
... that retinal neuroprogenitor cells are a crucial component of the developing neurovascular unit. Hif2a Epas1 Retina Neuroprogenitor Endostatin Angiogenesis Cre/lox Oxygen is fundamental for the development, specialization and survival of multicellular organisms ( Giaccia et al., 2004...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3994–4002.
Published: 01 November 2016
... , K. , Rattner , A. , Smallwood , P. , Zibetti , C. , Hirokawa , K. , Monuki , E. S. , Campochiaro , P. A. and Blackshaw , S. ( 2012 ). Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3582–3590.
Published: 01 October 2016
... cells. To assess the number of tip cells, we stained retinas with the tip cell-specific marker ESM1 ( del Toro et al., 2010 ; Xu et al., 2014 ). As expected, only few single cells at the vascular front were stained in wild-type retinas ( Fig. 2 C, top panels) confirming that ESM1 is a reliable tip cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2829–2841.
Published: 01 August 2016
..., assuring generation of the proper number of the diverse neuronal and glial cell subtypes that constitute the functional retina in mammals. * These authors contributed equally to this work ‡ Author for correspondence ( ruthash@post.tau.ac.il ) Competing interests The authors declare...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 1859–1873.
Published: 01 June 2016
...Christopher P. Zelinka; Leo Volkov; Zachary A. Goodman; Levi Todd; Isabella Palazzo; William A. Bishop; Andy J. Fischer We investigate the roles of mTor signaling in the formation of Müller glia-derived progenitor cells (MGPCs) in the chick retina. During embryonic development, pS6 (a readout...
Includes: Supplementary data