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Keywords: Reprogramming
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Journal Articles
Journal: Development
Development (2023) 150 (24): dev202300.
Published: 11 December 2023
... in human cell programming offer the potential to manipulate cell identity and function but face many challenges. Recent breakthrough technologies hold promise for more precise and efficient cell engineering. Cell programming Genomic engineering Human cell fate Reprogramming Synthetic biology...
Journal Articles
Journal: Development
Development (2023) 150 (20): dev202008.
Published: 26 October 2023
... cardiomyocyte cell cycle reentry via inhibition of pyruvate dehydrogenase kinase 4 (PDK4) ( Fig. 2C ) ( Cardoso et al., 2020 ). Another important target that can promote adult heart regeneration is SDH, or mitochondrial complex II; mutations in Sdhb promote metabolic reprogramming in some types of cancer...
Journal Articles
Journal: Development
Development (2023) 150 (6): dev201391.
Published: 24 March 2023
... stem cells and their overexpression in more committed progenitors drives reprogramming to a naïve, self-renewing stem cell-like state. Crucially, individual Hox family members are expressed in a location-specific manner and their stem cell-promoting activity is only observed when the Hox gene...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (11): dev200854.
Published: 6 June 2022
... reprogramming contributes significantly to the dynamic gene expression during ZGA; however, the mechanism has yet to be resolved. Here, we find histone deacetylases 1 and 2 (HDAC1/2) can regulate ZGA through lysine deacetylase activity. Notably, in mouse embryos, overexpression of a HDAC1/2 dominant-negative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200361.
Published: 22 April 2022
... and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo reprogramming are a promising strategy for tissue regeneration and rejuvenation. However, little is known about the barriers that impair reprogramming...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev197392.
Published: 5 February 2021
... Gandhi , S. , Ezin , M. and Bronner , M. E. ( 2020 ). Reprogramming axial level identity to rescue neural-crest-related congenital heart defects . Dev. Cell 53 , 300 - 315.e4 . 10.1016/j.devcel.2020.04.005 Grande , M. T. , Sánchez-Laorden , B. , López-Blau , C...
Journal Articles
Journal: Development
Development (2020) 147 (16): dev189688.
Published: 26 August 2020
.... In terms of developmental potential, a totipotent cell differs from a pluripotent cell by its ability to develop into an entire organism by itself (see Box 1 and the accompanying piece by Riveiro and Brickman, 2020 ). Totipotency is established concomitantly with epigenetic reprogramming after...
Journal Articles
In collection:
Plant development
Journal: Development
Development (2020) 147 (13): dev188912.
Published: 8 July 2020
... morphology and fate-marker expression in embryos in which suspensor division was activated by different triggers to address the developmental paths towards reprogramming. Our results show that reprogramming of Arabidopsis suspensor cells towards embryonic identity is a specific cellular response...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev182170.
Published: 2 December 2019
... important in ensuring tissue integrity. Over the past decade, several approaches to experimentally reprogram cell fate have emerged. Importantly, efforts to improve and understand these approaches have uncovered novel molecular determinants that reinforce lineage commitment and help resist cell fate changes...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (17): dev179556.
Published: 2 September 2019
... expression and conversion of ∼40% of mature MG into a neuronal/RPC phenotype. Our results suggest that the differences in miRNA expression between MG and RPCs contribute to their difference in neurogenic potential, and that manipulations in miRNAs provide a new tool with which to reprogram MG for retinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev170266.
Published: 10 July 2019
...Michelle K. Y. Seah; Yaju Wang; Pierre-Alexis Goy; Hui Mun Loh; Wen Jun Peh; Diana H. P. Low; Brenda Y. Han; Esther Wong; Ei Leen Leong; Gernot Wolf; Slim Mzoughi; Heike Wollmann; Todd S. Macfarlan; Ernesto Guccione; Daniel M. Messerschmidt ABSTRACT Global epigenetic reprogramming is vital to purge...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177220.
Published: 21 June 2019
... using microfluidics and mRNA for reprogramming ( Giulitti et al., 2019 ). He highlighted how this method allowed them to generate human iPSCs that have a naïve-like state (i.e. naïve iPSCs; niPSCs). They are currently trying to understand why the microfluidic system is so much more efficient...
Journal Articles
Journal: Development
Development (2019) 146 (9): dev176974.
Published: 8 May 2019
... Reprogramming Tissue repair Wound healing One of the most stimulating forums for discussing advances and future perspectives in regeneration is the EMBO conference on the Molecular and Cellular Basis of Regeneration and Tissue Repair. In 2018, the 7th edition of this conference series was held...
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (11): dev163501.
Published: 8 June 2018
... disease-specific alterations in methylation patterns. In contrast, foetal-derived organoids underwent drastic methylation changes in vitro , suggesting an in vitro maturation that could be used to model epithelial development. One of the most striking examples of plasticity is the reprogramming...
Journal Articles
Journal: Development
Development (2018) 145 (6): dev157420.
Published: 14 March 2018
... ; Hall et al., 2009 ; Niwa et al., 2009 ). Moreover, these three Klf family members are functionally interchangeable in the reprogramming of somatic cells into iPSCs, when used in combination with Oct3/4 , Sox2 and Myc ( Nakagawa et al., 2008 ), and when singly overexpressed to force the conversion...
Journal Articles
Journal: Development
Development (2018) 145 (4): dev146506.
Published: 26 February 2018
.... , Farnsworth , C. L. , Koller , A. A. , Dasgupta , R. , Silva , J. C. , et al. ( 2012 ). Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system . Cell Stem Cell   11 , 783 - 798 . 10.1016/j.stem.2012.09.011 Cerletti , M. , Jang , Y. C...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156117.
Published: 8 January 2018
... is problematic in terms of low availability and high variability, and it is also associated with ethical concerns that vary between countries. For decades, the field has therefore investigated new scalable source of therapeutic cells from stem cells or via reprogramming. Now it is possible to generate authentic...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4496–4509.
Published: 15 December 2017
... Pluripotency Reprogramming Transcription Pluripotent cells reside naturally in the blastocyst of early mouse and human embryos and constitute the founder tissue of the embryo proper. Pluripotent stem cells (PSCs) that are capable of long-term self-renewal can be derived from the blastocyst ( Evans...