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Keywords: Reprogramming
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Journal Articles
Journal: Development
Development (2021) 148 (3): dev197392.
Published: 05 February 2021
..., in response to a damaging external stimulus, the epithelium reprograms into a more ‘developmental-like’ state to aid repair. Dr Klein also discussed how intestinal ATOH1 + secretory cells reprogram into multipotent stem cells after injury, giving rise to all colonic epithelial lineages after ablation...
Journal Articles
Journal: Development
Development (2020) 147 (16): dev189688.
Published: 26 August 2020
... (2CLCs), providing a reference for the community and clarifying what we know about 2CLC identity. 2-cell-like cells Early embryonic-like cells Expanded potential Reprogramming Totipotency Totipotent-like cells ‘What am I?’ wonders the 2-cell-like cell . Over the last two decades...
Journal Articles
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Plant development
Journal: Development
Development (2020) 147 (13): dev188912.
Published: 08 July 2020
... morphology and fate-marker expression in embryos in which suspensor division was activated by different triggers to address the developmental paths towards reprogramming. Our results show that reprogramming of Arabidopsis suspensor cells towards embryonic identity is a specific cellular response...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev182170.
Published: 02 December 2019
... important in ensuring tissue integrity. Over the past decade, several approaches to experimentally reprogram cell fate have emerged. Importantly, efforts to improve and understand these approaches have uncovered novel molecular determinants that reinforce lineage commitment and help resist cell fate changes...
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179556.
Published: 02 September 2019
... expression and conversion of ∼40% of mature MG into a neuronal/RPC phenotype. Our results suggest that the differences in miRNA expression between MG and RPCs contribute to their difference in neurogenic potential, and that manipulations in miRNAs provide a new tool with which to reprogram MG for retinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev170266.
Published: 10 July 2019
...Michelle K. Y. Seah; Yaju Wang; Pierre-Alexis Goy; Hui Mun Loh; Wen Jun Peh; Diana H. P. Low; Brenda Y. Han; Esther Wong; Ei Leen Leong; Gernot Wolf; Slim Mzoughi; Heike Wollmann; Todd S. Macfarlan; Ernesto Guccione; Daniel M. Messerschmidt ABSTRACT Global epigenetic reprogramming is vital to purge...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177220.
Published: 21 June 2019
... no competing or financial interests. 15 4 2019 21 5 2019 © 2019. Published by The Company of Biologists Ltd 2019 Summary: This Meeting Review reports on the main results presented 2nd SY-Stem Symposium held in March 2019. Organoids Pluripotency Reprogramming Single cell...
Journal Articles
Journal: Development
Development (2019) 146 (9): dev176974.
Published: 08 May 2019
... Reprogramming Tissue repair Wound healing One of the most stimulating forums for discussing advances and future perspectives in regeneration is the EMBO conference on the Molecular and Cellular Basis of Regeneration and Tissue Repair. In 2018, the 7th edition of this conference series was held...
Journal Articles
Journal: Development
Development (2018) 145 (22): dev168617.
Published: 21 November 2018
... Reprogramming Directed differentiation Improvements in transcription factor-mediated lineage conversion of cellular identity and differentiation of pluripotent stem cells increasingly allow access to previously inaccessible cell types ( Gopalakrishnan et al., 2015 ; Han et al., 2011 ; Ichida...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev163501.
Published: 08 June 2018
... in Vienna brought together emerging leaders in stem cell biology, who presented their wide-ranging high-quality research, laying the foundations for dynamic future collaborations. Stem cells Organoids Pluripotency Single-cell analysis RNA sequencing Reprogramming To relate the many basic...
Journal Articles
Journal: Development
Development (2018) 145 (6): dev157420.
Published: 14 March 2018
... Summary: This Review summarizes how tissue-specific TFs cooperate with each other and super-enhancers to determine cell types, the mechanisms of redundancy and stability in such networks, and how they are rewired during mESC differentiation. Embryonic stem cells Differentiation Reprogramming...
Journal Articles
Journal: Development
Development (2018) 145 (4): dev146506.
Published: 26 February 2018
... by The Company of Biologists Ltd 2018 Summary: This Review summarizes the role of autophagy in embryonic, adult and cancer stem cells and cellular reprogramming, and highlights the consequences of autophagy dysregulation on tissue development and homeostasis. Autophagy Cancer stem cells Mitophagy...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156117.
Published: 08 January 2018
... is problematic in terms of low availability and high variability, and it is also associated with ethical concerns that vary between countries. For decades, the field has therefore investigated new scalable source of therapeutic cells from stem cells or via reprogramming. Now it is possible to generate authentic...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4496–4509.
Published: 15 December 2017
... , Z. , Tian , Y. , Zhang , Y. , Yang , W. , Gruber , P. J. , Epstein , J. A. , et al. ( 2011 ). Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency . Cell Stem Cell   8 , 376 - 388 . 10.1016/j.stem.2011.03.001 Arduini , B...
Journal Articles
Journal: Development
Development (2017) 144 (15): 2748–2763.
Published: 01 August 2017
... , B. and Salzberg , S. L. ( 2012 ). Fast gapped-read alignment with Bowtie 2 . Nat. Meth.   9 , 357 - 359 . Lee , H. J. , Hore , T. A. and Reik , W. ( 2014 ). Reprogramming the methylome: erasing memory and creating diversity . Cell Stem Cell   14 , 710 - 719...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2323–2337.
Published: 01 July 2017
... haematopoietic stem cells in vitro . HSC Human Embryo hPSC Reprogramming The selective expression of HOXA genes in human foetal liver and UCB-derived haematopoietic progenitor and stem cells clearly distinguished them from PSC-derived haematopoietic progenitors generated using...
Journal Articles
Journal: Development
Development (2016) 143 (23): 4301–4311.
Published: 01 December 2016
... to cell cycle transitions in dividing cells. These phenomena have been investigated in the context of reprogramming, differentiation and trans -differentiation but the underpinning molecular mechanisms remain unclear. Most progress to address the connection between cell fate and the cell cycle has been...
Journal Articles
Journal: Development
Development (2016) 143 (20): 3650–3660.
Published: 15 October 2016
... to govern the fine balance between TSC self-renewal and differentiation. In addition, breakthroughs in reprogramming strategies have enabled the generation of TSCs from fibroblasts, opening up exciting new avenues that may allow the isolation of this stem cell type from other species, notably humans. Here...
Journal Articles
Journal: Development
Development (2016) 143 (16): 2877–2881.
Published: 15 August 2016
... and adult stem cell biology were discussed, including their respective niches in ageing, disease and regeneration. Many presentations focused on emerging technologies, including single-cell analysis, in vitro organogenesis and direct reprogramming. Here, we summarize the data presented at this exciting...
Journal Articles
Journal: Development
Development (2016) 143 (10): 1644–1648.
Published: 15 May 2016
... developmental stages. By contrast, pluripotency can be captured and stabilized indefinitely in cell culture and can also be reactivated in differentiated cells via nuclear reprogramming. Pluripotent stem cells (PSCs) are the in vitro carriers of pluripotency and they can inhabit discrete pluripotent states...