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Keywords: Reprogramming
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Journal Articles
Journal: Development
Development (2023) 150 (2): dev201155.
Published: 18 January 2023
... and development. Pluripotency Reprogramming Transcription factor Gene duplication Pseudogene Evolution Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 BBS/E/B/000C0421 BBS/E/B/000C0422 Because NANOG has a central role in regulating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (11): dev200854.
Published: 6 June 2022
... reprogramming contributes significantly to the dynamic gene expression during ZGA; however, the mechanism has yet to be resolved. Here, we find histone deacetylases 1 and 2 (HDAC1/2) can regulate ZGA through lysine deacetylase activity. Notably, in mouse embryos, overexpression of a HDAC1/2 dominant-negative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200361.
Published: 22 April 2022
... and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo reprogramming are a promising strategy for tissue regeneration and rejuvenation. However, little is known about the barriers that impair reprogramming...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev197392.
Published: 5 February 2021
... Gandhi , S. , Ezin , M. and Bronner , M. E. ( 2020 ). Reprogramming axial level identity to rescue neural-crest-related congenital heart defects . Dev. Cell 53 , 300 - 315.e4 . 10.1016/j.devcel.2020.04.005 Grande , M. T. , Sánchez-Laorden , B. , López-Blau , C...
Journal Articles
Journal: Development
Development (2020) 147 (16): dev189688.
Published: 26 August 2020
... (2CLCs), providing a reference for the community and clarifying what we know about 2CLC identity. 2-cell-like cells Early embryonic-like cells Expanded potential Reprogramming Totipotency Totipotent-like cells ‘What am I?’ wonders the 2-cell-like cell . Over the last two decades...
Journal Articles
In collection:
Plant development
Journal: Development
Development (2020) 147 (13): dev188912.
Published: 8 July 2020
... morphology and fate-marker expression in embryos in which suspensor division was activated by different triggers to address the developmental paths towards reprogramming. Our results show that reprogramming of Arabidopsis suspensor cells towards embryonic identity is a specific cellular response...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev182170.
Published: 2 December 2019
... important in ensuring tissue integrity. Over the past decade, several approaches to experimentally reprogram cell fate have emerged. Importantly, efforts to improve and understand these approaches have uncovered novel molecular determinants that reinforce lineage commitment and help resist cell fate changes...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (17): dev179556.
Published: 2 September 2019
... expression and conversion of ∼40% of mature MG into a neuronal/RPC phenotype. Our results suggest that the differences in miRNA expression between MG and RPCs contribute to their difference in neurogenic potential, and that manipulations in miRNAs provide a new tool with which to reprogram MG for retinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev170266.
Published: 10 July 2019
...Michelle K. Y. Seah; Yaju Wang; Pierre-Alexis Goy; Hui Mun Loh; Wen Jun Peh; Diana H. P. Low; Brenda Y. Han; Esther Wong; Ei Leen Leong; Gernot Wolf; Slim Mzoughi; Heike Wollmann; Todd S. Macfarlan; Ernesto Guccione; Daniel M. Messerschmidt ABSTRACT Global epigenetic reprogramming is vital to purge...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177220.
Published: 21 June 2019
... for reprogramming ( Giulitti et al., 2019 ). He highlighted how this method allowed them to generate human iPSCs that have a naïve-like state (i.e. naïve iPSCs; niPSCs). They are currently trying to understand why the microfluidic system is so much more efficient in reprogramming and whether there are factors...
Journal Articles
Journal: Development
Development (2019) 146 (9): dev176974.
Published: 8 May 2019
... Reprogramming Tissue repair Wound healing One of the most stimulating forums for discussing advances and future perspectives in regeneration is the EMBO conference on the Molecular and Cellular Basis of Regeneration and Tissue Repair. In 2018, the 7th edition of this conference series was held...
Journal Articles
Journal: Development
Development (2018) 145 (22): dev168617.
Published: 21 November 2018
... , M. J. , Lake , A. M. , Ouwenga , R. , Lee , S. W. , Xing , X. , Li , D. , Lee , H. J. , Heuckeroth , R. O. , et al. ( 2017 ). MicroRNAs induce a permissive chromatin environment that enables neuronal subtype-specific reprogramming of adult human fibroblasts . Cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev163501.
Published: 8 June 2018
... ( Fig. 2 ). The meeting covered enormous territory over 3 days, spanning a diverse range of topics from the nature of primed versus naïve pluripotency to transcriptional mechanisms governing endogenous regeneration and cellular reprogramming, as well as clinical applications of stem cell and organoid...
Journal Articles
Journal: Development
Development (2018) 145 (6): dev157420.
Published: 14 March 2018
... cooperate with each other and super-enhancers to determine cell types, the mechanisms of redundancy and stability in such networks, and how they are rewired during mESC differentiation. Embryonic stem cells Differentiation Reprogramming Transcription factor During mouse development...
Journal Articles
Journal: Development
Development (2018) 145 (4): dev146506.
Published: 26 February 2018
... , A. A. , Dasgupta , R. , Silva , J. C. , et al. ( 2012 ). Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system . Cell Stem Cell   11 , 783 - 798 . 10.1016/j.stem.2012.09.011 Cerletti , M. , Jang , Y. C. , Finley , L. W. , Haigis , M. C...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156117.
Published: 8 January 2018
... is problematic in terms of low availability and high variability, and it is also associated with ethical concerns that vary between countries. For decades, the field has therefore investigated new scalable source of therapeutic cells from stem cells or via reprogramming. Now it is possible to generate authentic...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4496–4509.
Published: 15 December 2017
... in Fig. 3 . Fig. 3. Molecular dynamics during the transitions into and out of human pluripotency. Summary of the transcriptional and epigenetic changes during cell fate transitions involving hPSCs. (A) Sequence of events occurring during the reprogramming of human somatic cells to pluripotency...
Journal Articles
Journal: Development
Development (2017) 144 (15): 2748–2763.
Published: 1 August 2017
... ), consistent with metabolic reprogramming between primed and naïve pluripotency ( Takashima et al., 2014 ; Zhou et al., 2012 ). Overall, cR cells share global gene expression features with ICM-derived HNES cells and transgene-reset PSCs and are distinct from various primed PSCs. Genes highly upregulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2323–2337.
Published: 1 July 2017
... haematopoietic stem cells in vitro . HSC Human Embryo hPSC Reprogramming In mammals, the first transient waves of blood cells arise in the yolk sac (extra-embryonic haematopoiesis) and serve the immediate needs of the growing embryo ( Silver and Palis, 1997 ). They include the most primitive...
Journal Articles
Journal: Development
Development (2016) 143 (23): 4301–4311.
Published: 1 December 2016
... to cell cycle transitions in dividing cells. These phenomena have been investigated in the context of reprogramming, differentiation and trans -differentiation but the underpinning molecular mechanisms remain unclear. Most progress to address the connection between cell fate and the cell cycle has been...