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Keywords: Regulatory network
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Journal Articles

A developmental stage-specific network approach for studying dynamic co-regulation of transcription factors and microRNAs during craniofacial development

Fangfang Yan, Peilin Jia, Hiroki Yoshioka, Akiko Suzuki, Junichi Iwata, Zhongming Zhao
Journal: Development
Development (2020) 147 (24): dev192948.
DOI: https://doi.org/10.1242/dev.192948
Published: 24 December 2020
.... and Zhao , Z. ( 2010 ). A novel microRNA and transcription factor mediated regulatory network in schizophrenia . BMC Syst. Biol.   4 , 10 . 10.1186/1752-0509-4-10 He , X.-X. , Chang , Y. , Meng , F.-Y. , Wang , M.-Y. , Xie , Q.-H. , Tang , F. , Li , P.-Y. , Song...
View article titled, A developmental stage-specific network approach for studying dynamic co-regulation of transcription factors and microRNAs during craniofacial development
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Includes: Supplementary data
Journal Articles

Regulatory integration of Hox factor activity with T-box factors in limb development

In collection:
Chromatin & epigenetics , Musculoskeletal system
Deepak Jain, Stephen Nemec, Maëva Luxey, Yves Gauthier, Amandine Bemmo, Aurelio Balsalobre, Jacques Drouin
Journal: Development
Development (2018) 145 (6): dev159830.
DOI: https://doi.org/10.1242/dev.159830
Published: 22 March 2018
...-restricted transcription factors Tbx4, Hoxc10 and Pitx1, and identify a novel composite T-box–Hox DNA motif that integrates Hox modulation of Tbx-dependent transcription. Limb specification Regulatory network ChIPseq Tbx4 Hoxc10 Pitx1 Tbx5 Hoxa13 Hoxd13 Tetrapod limbs develop under...
View article titled, Regulatory integration of Hox factor activity with T-box factors in limb development
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Includes: Supplementary data
Journal Articles

Pitx1 directly modulates the core limb development program to implement hindlimb identity

In collection:
Musculoskeletal system
Stephen Nemec, Maëva Luxey, Deepak Jain, Aurélie Huang Sung, Tomi Pastinen, Jacques Drouin
Journal: Development
Development (2017) 144 (18): 3325–3335.
DOI: https://doi.org/10.1242/dev.154864
Published: 15 September 2017
... display HL-like patterning features ( Spielmann et al., 2012 ). The breadth and characteristics of the Pitx1 -directed HL program are not well understood: what is the extent of Pitx1 -dependent gene regulation and to what extent is this Pitx1 -dependent gene regulatory network unique to the HL...
View article titled, Pitx1 directly modulates the core limb development program to implement hindlimb identity
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Includes: Supplementary data
Journal Articles

Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators

Lori L. O'Brien, Qiuyu Guo, YoungJin Lee, Tracy Tran, Jean-Denis Benazet, Peter H. Whitney, Anton Valouev, Andrew P. McMahon
Journal: Development
Development (2016) 143 (4): 595–608.
DOI: https://doi.org/10.1242/dev.127175
Published: 15 February 2016
... Ltd 2016 Highlighted article: A comparison of Six2/SIX2 regulatory targets in mouse and human nephron progenitors reveals that Six1/SIX1 is differentially regulated and expressed between the two species. Nephrogenesis Nephron Regulatory network Six1/2 Transcription Nephrons...
View article titled, Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators
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Includes: Supplementary data
Journal Articles

A computational model for the coordination of neural progenitor self-renewal and differentiation through Hes1 dynamics

In collection:
Stem cells & regeneration
Benjamin Pfeuty
Journal: Development
Development (2015) 142 (3): 477–485.
DOI: https://doi.org/10.1242/dev.112649
Published: 1 February 2015
...., 2009 ). The mathematical model used here to explore the connection between cell cycle dynamics and Notch signaling in neural progenitors consists of a regulatory network that encompasses cell cycle regulators, the transcription factor Ngn2, the Notch effector Hes1 and the Delta-like Notch ligand Dll1...
View article titled, A computational model for the coordination of neural progenitor self-renewal and differentiation through Hes1 dynamics
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Includes: Supplementary data
Journal Articles

How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation

Mark D. Schroeder, Christina Greer, Ulrike Gaul
Journal: Development
Development (2011) 138 (14): 3067–3078.
DOI: https://doi.org/10.1242/dev.062141
Published: 15 July 2011
... formation Transcription control Cis-regulatory element Regulatory network Long-range regulation Drosophila The Drosophila segmentation genes ( Nusslein-Volhard et al., 1987 ; Nusslein-Volhard and Wieschaus, 1980 ) form a hierarchical regulatory network consisting of the maternal, gap, pair...
View article titled, How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation
Click here to open pdf in another window PDF for How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation
Includes: Supplementary data
Journal Articles

Repression of mesodermal fate by foxa , a key endoderm regulator of the sea urchin embryo

Paola Oliveri, Katherine D. Walton, Eric H. Davidson, David R. McClay
Journal: Development
Development (2006) 133 (21): 4173–4181.
DOI: https://doi.org/10.1242/dev.02577
Published: 1 November 2006
...Paola Oliveri; Katherine D. Walton; Eric H. Davidson; David R. McClay The foxa gene is an integral component of the endoderm specification subcircuit of the endomesoderm gene regulatory network in the Strongylocentrotus purpuratus embryo. Its transcripts become confined to veg2, then veg1...
View article titled, Repression of mesodermal fate by foxa , a key endoderm regulator of the sea urchin embryo
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Journal Articles

The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo

L. Ryan Baugh, Andrew A. Hill, Julia M. Claggett, Kate Hill-Harfe, Joanne C. Wen, Donna K. Slonim, Eugene L. Brown, Craig P. Hunter
Journal: Development
Development (2005) 132 (8): 1843–1854.
DOI: https://doi.org/10.1242/dev.01782
Published: 15 April 2005
..., which together with their spatial expression patterns leads to a model of the regulatory network specified by PAL-1. § Author for correspondence (e-mail: hunter@mcb.harvard.edu ) * Present address: Biology Division, California Institute of Technology,Pasadena, CA 91125, USA † Division...
View article titled, The homeodomain protein PAL-1 specifies a lineage-specific <span class="search-highlight">regulatory</span> <span class="search-highlight">network</span> in the C. elegans embryo
Click here to open pdf in another window PDF for The homeodomain protein PAL-1 specifies a lineage-specific <span class="search-highlight">regulatory</span> <span class="search-highlight">network</span> in the C. elegans embryo
Includes: Multimedia, Supplementary data