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Keywords: Regeneration
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev197087.
Published: 23 April 2021
...José Esteban-Collado; Montserrat Corominas; Florenci Serras ABSTRACT Regeneration after damage requires early signals to trigger the tissue repair machinery. Reactive oxygen species (ROS) act as early signals that are sensed by the MAP3 kinase Ask1, which in turn activates by phosphorylation the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev195347.
Published: 24 March 2021
... from the regeneration of specific cell types, tissues and organs, to the rebuilding of an entire organism. Over the years, extensive studies on embryo, shoot and root development in the model plant species Arabidopsis thaliana have provided insights into the mechanisms underlying plant regeneration...
Journal Articles
Journal: Development
Development (2021) 148 (6): dev195057.
Published: 19 March 2021
...Danielle DaCrema; Rajan Bhandari; Faith Karanja; Ryunosuke Yano; Adrian Halme ABSTRACT Regeneration of Drosophila imaginal discs, larval precursors to adult tissues, activates a regeneration checkpoint that coordinates regenerative growth with developmental progression. This regeneration checkpoint...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev187534.
Published: 10 March 2021
...Ismael Fernández-Hernández; Evan B. Marsh; Michael A. Bonaguidi ABSTRACT Auditory and vestibular mechanosensory hair cells do not regenerate following injury or aging in the adult mammalian inner ear, inducing irreversible hearing loss and balance disorders for millions of people. Research on model...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev195495.
Published: 08 February 2021
... classical activation by the TGFβ receptor complex. Loss of Smad2 in muscle satellite cells in vivo resulted in decreased muscle fiber caliber and impaired regeneration after acute injury. Taken together, we demonstrate that SMAD2 is an important positive regulator of myogenic differentiation, in part...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev195339.
Published: 26 January 2021
...Maria Ohno; Masataka Nikaido; Natsumi Horiuchi; Koichi Kawakami; Kohei Hatta ABSTRACT The enteric nervous system (ENS), which is derived from neural crest, is essential for gut function, and its deficiency causes severe congenital diseases. Since the capacity for ENS regeneration in mammals is...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev194027.
Published: 15 January 2021
...) to migrate during embryonic development, the regulation of EMT in post-natal myogenesis remains poorly understood. Here, we demonstrate that the long noncoding RNA (lncRNA) Meg3 regulates EMT in myoblast differentiation and skeletal muscle regeneration. Chronic inhibition of Meg3 in C2C12 myoblasts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev196063.
Published: 11 January 2021
... organisms. This research tackles several aspects of developmental biology and integrates inputs from physics, mathematical modelling and evolutionary biology. Although many open questions remain, this work also helps to shed light on medically related conditions such as tissue and limb regeneration, as well...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev194019.
Published: 23 December 2020
...Ian J. Begeman; Kwangdeok Shin; Daniel Osorio-Méndez; Andrew Kurth; Nutishia Lee; Trevor J. Chamberlain; Francisco J. Pelegri; Junsu Kang ABSTRACT Heart regeneration in regeneration-competent organisms can be accomplished through the remodeling of gene expression in response to cardiac injury. This...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev193714.
Published: 19 November 2020
...Anael Soubigou; Ethan G. Ross; Yousef Touhami; Nathan Chrismas; Vengamanaidu Modepalli ABSTRACT Somatic cells dissociated from an adult sponge can reorganize and develop into a juvenile-like sponge, a remarkable phenomenon of regeneration. However, the extent to which regeneration recapitulates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193193.
Published: 23 October 2020
...-resolution imaging, can extend the scope of neural crest lineage studies beyond development to regeneration and cancer initiation. * Author for correspondence ( mbronner@caltech.edu ) Competing interests The authors declare no competing or financial interests. © 2020. Published by The...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev194233.
Published: 21 October 2020
... the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192807.
Published: 09 October 2020
... maintained in a lineage-restricted manner during homeostasis or after mild injuries. Glandular regeneration following a near complete loss of secretory cells, however, may involve cellular plasticity, although the mechanism and extent of such plasticity remain unclear. Here, by combining lineage-tracing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev191262.
Published: 30 July 2020
...John D. Thompson; Jianhong Ou; Nutishia Lee; Kwangdeok Shin; Valentina Cigliola; Lingyun Song; Gregory E. Crawford; Junsu Kang; Kenneth D. Poss ABSTRACT To identify candidate tissue regeneration enhancer elements (TREEs) important for zebrafish fin regeneration, we performed ATAC-seq from bulk...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev184895.
Published: 03 June 2020
...An Yan; Michael Borg; Frédéric Berger; Zhong Chen ABSTRACT Plants are capable of regenerating new organs after mechanical injury. The regeneration process involves genome-wide reprogramming of transcription, which usually requires dynamic changes in the chromatin landscape. We show that the histone...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183418.
Published: 22 May 2020
...Isabella Palazzo; Kyle Deistler; Thanh V. Hoang; Seth Blackshaw; Andy J. Fischer ABSTRACT Retinal regeneration is robust in some cold-blooded vertebrates, but this process is ineffective in warm-blooded vertebrates. Understanding the mechanisms that suppress the reprogramming of Müller glia into...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev186569.
Published: 27 April 2020
... differential state of multiple cell types, during both development and adulthood. Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absence of runx1 results in increased myocardial survival and proliferation, and overall heart regeneration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev184044.
Published: 08 April 2020
... regeneration and increases cell number during homeostasis. Importantly, this increase in cell number leads to an increase in body size only in a nutrient-rich environment; in starved planarians, silencing results in a decrease in cell size and cell accumulation that ultimately produces overgrowths. bls...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev173781.
Published: 06 April 2020
...Donald T. Fox; Erez Cohen; Rachel Smith-Bolton ABSTRACT Drosophila melanogaster has historically been a workhorse model organism for studying developmental biology. In addition, Drosophila is an excellent model for studying how damaged tissues and organs can regenerate. Recently, new precision...
Journal Articles
Journal: Development
Development (2020) 147 (6): dev180844.
Published: 19 March 2020
...Lauren S. Phipps; Lindsey Marshall; Karel Dorey; Enrique Amaya ABSTRACT Understanding how to promote organ and appendage regeneration is a key goal of regenerative medicine. The frog, Xenopus , can achieve both scar-free healing and tissue regeneration during its larval stages, although it...