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Keywords: Regeneration
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Journal Articles
Journal: Development
Development (2022) 149 (12): dev200303.
Published: 20 June 2022
... attributed. Summary: Two adjacent extra-embryonic tissues, the area opaca and the marginal zone, interact to influence the polarity of the early chick embryo. Gastrulation Embryo polarity Embryonic axis Symmetry breaking Embryonic regulation Regeneration Wellcome Trust http...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (10): dev200277.
Published: 19 May 2022
...Hannah Brunsdon; Alessandro Brombin; Samuel Peterson; John H. Postlethwait; E. Elizabeth Patton ABSTRACT Melanocyte stem cells (McSCs) in zebrafish serve as an on-demand source of melanocytes during growth and regeneration, but metabolic programs associated with their activation and regenerative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200113.
Published: 3 May 2022
...Amanda S. Janesick; Mirko Scheibinger; Nesrine Benkafadar; Sakin Kirti; Stefan Heller ABSTRACT The avian hearing organ is the basilar papilla that, in sharp contrast to the mammalian cochlea, can regenerate sensory hair cells and thereby recover from deafness within weeks. The mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199906.
Published: 3 May 2022
... repair by scar formation and the initiation of tissue regeneration. They initially assume inflammatory phenotypes, releasing pro-inflammatory cytokines and removing dead and dying tissue, before entering a reparative stage, replacing dead muscle tissue with a non-contractile scar. In this Review, we...
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199903.
Published: 3 May 2022
... repair and regeneration. We conclude by suggesting that comprehensive analyses of the immune system may enable biomedical applications in stem cell biology and regenerative medicine. Summary: This Spotlight discusses non-traditional roles of immune and non-immune-like cells, and their interactions...
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200125.
Published: 30 March 2022
...Nicolle A. Bonar; David I. Gittin; Christian P. Petersen ABSTRACT Tissue identity determination is crucial for regeneration, and the planarian anteroposterior (AP) axis uses positional control genes expressed from body wall muscle to determine body regionalization. Canonical Wnt signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200112.
Published: 25 March 2022
... in skeletal muscle regeneration and, in the absence of eosinophil-secreted interleukin (IL) 4 and IL13, fibro-adipogenic progenitors fail to support muscle stem cell proliferation. However, the role of eosinophils in muscular dystrophy remains elusive. Although it has been shown that eosinophils are present...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev199637.
Published: 17 March 2022
...Timothy J. Duerr; Eun Kyung Jeon; Kaylee M. Wells; Antonio Villanueva; Ashley W. Seifert; Catherine D. McCusker; James R. Monaghan ABSTRACT Regulation of cell cycle progression is essential for cell proliferation during regeneration following injury. After appendage amputation, the axolotl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (5): dev199995.
Published: 11 March 2022
... that canonical Notch signaling is induced during the initial stages of cartilage callus formation in both mesenchymal cells and chondrocytes following surgical mandibulectomy. We also show that modulation of Notch signaling during the initial post-operative period results in lasting changes to regenerate bone...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (5): dev200127.
Published: 4 March 2022
... and fatty acid synthase are required for the formation of Müller glia-derived progenitors in the retina. Muller glia Regeneration Retina Fatty acids Chick National Institutes of Health http://dx.doi.org/10.13039/100000002 R01 EY032141-01 U01 EY027267-03 The peer review...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2022) 149 (5): dev200079.
Published: 28 February 2022
...Phanu T. Serivichyaswat; Kai Bartusch; Martina Leso; Constance Musseau; Akira Iwase; Yu Chen; Keiko Sugimoto; Marcel Quint; Charles W. Melnyk ABSTRACT Cellular regeneration in response to wounding is fundamental to maintain tissue integrity. Various internal factors including hormones...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200033.
Published: 14 February 2022
...Sarah E. Walker; Keith Z. Sabin; Micah D. Gearhart; Kenta Yamamoto; Karen Echeverri ABSTRACT Axolotls are an important model organism for multiple types of regeneration, including functional spinal cord regeneration. Remarkably, axolotls can repair their spinal cord after a small lesion injury...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev199449.
Published: 3 February 2022
... for stem cell dynamics involved in regeneration. These findings suggest that plac8-A acts as a molecular switch of piwi + stem cells for entry into the regenerative state after amputation. Although we reported that an aPSC-specific gene, P2X-A , which encodes an ATP-dependent ion channel, modulates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199853.
Published: 28 January 2022
...; Nikolay Ninov ABSTRACT Regeneration-competent species possess the ability to reverse the progression of severe diseases by restoring the function of the damaged tissue. However, the cellular dynamics underlying this capability remain unexplored. Here, we have used single-cell transcriptomics to map de...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199916.
Published: 9 November 2021
... by comparative RNA sequencing during leg regeneration. Of the 11 Toll genes in the Gryllus genome, expression of Toll2-1 , Toll2-2 and Toll2-5 was upregulated during regeneration. RNA interference (RNAi) of Toll , Toll2-1 , Toll2-2 , Toll2-3 or Toll2-4 produced regeneration defects in more than 50% of crickets...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199861.
Published: 5 November 2021
...Brittany C. Collins; Gabrielle Kardon ABSTRACT Vertebrate skeletal muscle is composed of multinucleate myofibers that are surrounded by muscle connective tissue. Following injury, muscle is able to robustly regenerate because of tissue-resident muscle stem cells, called satellite cells. In addition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199636.
Published: 26 October 2021
...). An attractive therapeutic strategy to treat MI is to reduce or remove infiltrating neutrophils to promote downstream reparative mechanisms. CDK9 inhibitor compounds enhance the resolution of neutrophilic inflammation; however, their effects on cardiac repair/regeneration are unknown. We have devised a cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199740.
Published: 13 September 2021
...Hessel Honkoop; Phong D. Nguyen; Veronique E. M. van der Velden; Katharina F. Sonnen; Jeroen Bakkers ABSTRACT Zebrafish are excellent at regenerating their heart by reinitiating proliferation in pre-existing cardiomyocytes. Studying how zebrafish achieve this holds great potential in developing new...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199577.
Published: 6 September 2021
...Lois A. Salamonsen; Jennifer C. Hutchison; Caroline E. Gargett ABSTRACT Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes...
Journal Articles
Journal: Development
Development (2021) 148 (15): dev196097.
Published: 2 August 2021
.... At publication, PLANA contains over 850 terms describing Smed anatomy from subcellular to system levels across all life cycle stages, in intact animals and regenerating body fragments. Terms from other anatomy ontologies were imported into PLANA to promote interoperability and comparative anatomy studies...
Includes: Supplementary data