... and stellate ocean cells, in addition to the inhibitory interneurons. Ocean cells express reelin and surround clusters of island cells that lack reelin expression. The influence of reelin expression by ocean cells and interneurons on their own morphological differentiation and that of MECII island cells has...

...Mohammad I. K. Hamad; Petya Petrova; Solieman Daoud; Obada Rabaya; Abdalrahim Jbara; Nesrine Melliti; Jennifer Leifeld; Igor Jakovčevski; Gebhard Reiss; Joachim Herz; Eckart Förster ABSTRACT Reelin is a large secreted glycoprotein that regulates neuronal migration, lamination and establishment...

...Yuki Hirota; Kazunori Nakajima ABSTRACT In the developing neocortex, radially migrating neurons stop migration and form layers beneath the marginal zone (MZ). Reelin plays essential roles in these processes via its receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein...

... the fast evolution of the human cortex. Cajal-Retzius cells Cortical folding Neural progenitors Neural stem cells Reelin Fonds de la Recherche Scientifique FNRS PDR T0002.13 FNRS PDR T00075.15 Interuniversity Poles of Attraction PAI p6/20 PAI7/20 WELBIO...

... and then tangentially, whereas neurons destined for the medial VTA undergo primarily radial migration. We show that tangentially migrating dopaminergic neurons express the components of the reelin signaling pathway, whereas dopaminergic neurons in their initial, radial migration phase express CXC chemokine receptor 4...

...Jarmila Lakomá; Luis Garcia-Alonso; Juan M. Luque Migration of neurons during cortical development is often assumed to rely on purely post-proliferative reelin signaling. However, Notch signaling, long known to regulate neural precursor formation and maintenance, is required for the effects...

... about their origin and development. Previous studies suggest that they originate in the medial ganglionic eminence of the telencephalic subpallium; however, our results identified Tbr1 -expressing, reelin-positive neurons migrating from the ventral pallium to the subpallium that differentiate...

... and accumulate below the preplate. The basement membrane is disrupted and radial glial processes are disorganised and lack attachment in C3G-deficient brains. C3G is activated in response to reelin in cortical neurons, which, in turn, leads to activation of the small GTPase Rap1. In C3G-deficient cells, Rap1 GTP...

...Iris Hack; Sabine Hellwig; Dirk Junghans; Bianka Brunne; Hans H. Bock; Shanting Zhao; Michael Frotscher Reelin, its lipoprotein receptors [very low density lipoprotein receptor(Vldlr) and apolipoprotein E receptor 2 (ApoER2; also known as Lrp8)], and the cytoplasmic adaptor protein disabled 1 (Dab1...

... in the olfactory placode and migrate into the basal forebrain in late embryonic life. Here, we show that reelin, which is expressed along the route of the migrating cells, has an inhibitory role in guiding GnRH neurons to the basal forebrain. Only a small(approximately 5%) subpopulation of these neurons expresses...

...Shanting Zhao; Xuejun Chai; Eckart Förster; Michael Frotscher Reelin is required for the proper positioning of neurons in the cerebral cortex. In the reeler mutant lacking reelin, the granule cells of the dentate gyrus fail to form a regular, densely packed cell layer. Recent evidence suggests...

...Tara M. Herrick; Jonathan A. Cooper The disabled 1 (Dab1) p80 protein is essential for reelin signaling during brain development. p80 has an N-terminal domain for association with reelin receptors, followed by reelin-dependent tyrosine phosphorylation sites and about 310 C-terminal residues...