... 85 candidate proteins, the majority of which are conserved in humans. Many of these proteins are expressed in the ventral nerve cord, and gene ontology, pathway analysis and biochemical validation identified several previously unreported pathways, including the receptor tyrosine phosphatase Lar...

..., A. and Ish-Horowicz, D. ( 2003 ). Chick receptor tyrosine phosphatase Psi is dynamically expressed during somitogenesis. Gene Expr. Patt. 3 , 325 -329. Akimenko, M. A., Ekker, M., Wegner, J., Lin, W. and Westerfield,M. ( 1994 ). Combinatorial expression of three zebrafish genes related to distal...

.... and Notkins, A. L. ( 2001 ). The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish. Diabetologia 44 , 81 -88. Desai, C. J., Popova, E. and Zinn, K. ( 1994 ). A Drosophila receptor tyrosine phosphatase expressed in the embryonic cns and larval optic lobes is a member...

... for correspondence (e-mail: [email protected] ) 22 11 1999 26 01 2000 © 2000 by Company of Biologists 2000 Neural development Drosophila Neurogenetics Receptor tyrosine phosphatase Tyrosine phosphorylation Growth cone repulsion Axon guidance roundabout commissureless...

... this system, we recovered new alleles of the gene encoding the receptor tyrosine phosphatase PTP69D. PTP69D has previously been shown to function in the correct targeting of motor axons in the embryo and R1-R6 axons in the visual system. Here, we show that PTP69D is also required for correct targeting of R7...

... processes, are thought to accomplish this navigation through receptors that recognize guidance cues and modulate growth accordingly. In Drosophila , several receptor tyrosine phosphatases (rPTPs), including DLAR, have been shown to participate in directing neurite outgrowth. As yet, however, it is not known...

...Chand J. Desai; Neil X. Krueger; Haruo Saito; Kai Zinn ABSTRACT The neural receptor tyrosine phosphatases DPTP69D, DPTP99A and DLAR are involved in motor axon guidance in the Drosophila embryo. Here we analyze the requirements for these three phosphatases in growth cone guidance decisions along...