... data also suggest that the implantation chamber facilitates embryo rotation and its alignment along the uterine mesometrial-antimesometrial axis. Using WNT5A- and RBPJ-deficient mice that display aberrant folds, we show that embryos trapped in longitudinal folds display misalignment of the embryo...

... whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed...

... to the formation of individual placodes. Epibranchial placode Pharyngeal ectoderm Notch signalling N1ICD Rbpj Mouse Cranial placodes are transient ectodermal thickenings that give rise to specialized sensory organs and ganglia of the cephalic peripheral nervous system. Cranial placodes arise...

... signaling in Sertoli cells has not been demonstrated. To this end, we conditionally ablated recombination signal binding protein for immunoglobulin kappa J region ( Rbpj ), a crucial mediator of NOTCH signaling, in Sertoli cells using Amh-cre . Rbpj knockout mice had: significantly increased testis sizes...

... embryonic AV specification by promoting arterial, as opposed to venous, endothelial cell (EC) fate. To understand the essential role of endothelial Notch signaling in postnatal AV organization, we used inducible Cre-lox P recombination to delete Rbpj , a mediator of canonical Notch signaling, from postnatal...

... cells with high Pax7 expression. By genetically modulating Notch activity, we demonstrate that activated Notch (NICD) blocks terminal differentiation in an Rbpj-dependent manner that is sufficient to sustain stem/progenitor cells throughout embryogenesis, despite the absence of committed progeny...

...Hassan Nakhai; Jens T. Siveke; Bettina Klein; Lidia Mendoza-Torres; Pawel K. Mazur; Hana Algül; Freddy Radtke; Lothar Strobl; Ursula Zimber-Strobl; Roland M. Schmid The role of the Notch signaling members Notch1, Notch2 and Rbpj in exocrine pancreatic development is not well defined. We therefore...