... caused by a null mutation in the tumor-suppressor and class B synMuv gene lin-35 Rb and a gain-of-function mutation in let-60 Ras are suppressed by reduction of isw-1 function,NURF complex proteins might be effective targets for cancer therapy. Loss-of-function mutations in the synthetic multivulva...

...Kathryn A. Wikenheiser-Brokamp pRb, p107 and p130 are important regulators of cell cycle and have extensive overlapping functions; however, only Rb has been shown to be a bone fide tumor suppressor. Defining the overlapping versus distinct pocket protein functions is therefore an important step...

...Silvia Marino; Dennis Hoogervoorst; Sebastian Brandner; Anton Berns The involvement of the retinoblastoma gene product (Rb) and its family members (p107 and p130) in cell cycle exit and terminal differentiation of neural precursor cells has been demonstrated in vitro. To investigate the roles of Rb...

... and of spermatid differentiation genes, and for maintenance of normal chromatin structure in primary spermatocytes. We show that aly encodes a homologue of the Caenorhabditis elegans gene lin-9 , a negative regulator of vulval development that acts in the same SynMuvB genetic pathway as the LIN-35 Rb-like protein...