... to exit the placenta and invade into the uterus where they restructure the vasculature. Invasive trophoblast cells arise from a well-defined compartment within the placenta, referred to as the junctional zone in rat and the extravillous trophoblast cell column in human. In this study, we investigated...

... Nkx2-2 and Skor2, which are co-expressed in a restricted group of post-mitotic GABAergic precursors in the MRF. Both Gata2 and Nkx2-2 function is required for Skor2 expression in GABAergic precursors. In the adult mouse and rat midbrain, Nkx2-2 -and Skor2 -expressing GABAergic neurons locate...

...-gastrulating embryos in mammals, and subsequently migrate towards gonads to mature into functional gametes. Here, we investigated PGC development in rats, by genetically modifying Prdm14 , a unique marker and an essential PGC transcriptional regulator. We trace PGC development in rats, for the first time, from...

... Dendritic spines Structural plasticity Hippocampus NCAM Mouse Rat The development of complex, type-specific dendrite morphology and the formation of correct synaptic connections play major roles in governing the functional properties of neurons and neural circuits ( Gulledge et al., 2005...

... induce death of sensory neurons in vitro . The extent to which Sema3A regulates developmental cell death in vivo , however, is debated. We show that in compartmentalized cultures of rat sympathetic neurons, a Sema3A-initiated apoptosis signal is retrogradely transported from axon terminals to cell bodies...

... experiments using postnatal or adult SVZ progenitors reveal key differences in the connective properties of the neurons generated. Adult neurogenesis Synaptic development Fate determination Subventricular zone Rat New neurons are continuously added to the adult mammalian brain. The most...

...) siRNA GFP vectors was the viral plasmid piLenti siRNA GFP (ABM), where the opposing polymerase III promoters (H1 and U6) transcribed the sense and antisense strands of the siRNA duplex and a CMV promoter driving GFP expression. The target sequence for rat Hmga2 siRNA was 5...

..., we reveal a novel function of pancortin in the migration of neuronal precursors into the cortical plate of the rat cortex. AMY knock down produces a phenotype in which neuronal precursors enter the cortical plate but exhibit abnormal positioning, a unique phenotype that we have not observed...

... (single XY) and z -stack series (XZ) of the organ of Corti from rat cochlear cultures electroporated with GFP and GFP-Vangl2 constructs (left panels), and labeled with anti-GFP antibody (green) and phalloidin (red). (E-F) The empty vector expressing GFP alone fills the cytoplasm of transfected HCs...

... neurons ( Fig. 3E,F ). * Author for correspondence ( stegmueller@em.mpg.de ) Competing interests statement The authors declare no competing financial interests. 11 7 2012 © 2012. Cdh1-APC Smurf1 Axon growth Myelin Ubiquitylation Mouse Rat Axon...

... Oligodendroglial differentiation Multiple sclerosis Regeneration Spinal cord injury Rat Cdkn1c Adult neurogenesis mainly occurs in two regions of the central nervous system (CNS), the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the hippocampal...

.... Dendritogenesis Spinogenesis AMPA receptors Neocortex RNA splicing and editing Two-photon calcium imaging Rat Dendrites receive and integrate synaptic inputs, and during development dendritic trees grow under the control of neuronal activity. Studies have provided compelling support...

... a method for long-term videomicroscopy to follow the lineages of rat perinatal RPCs cultured at clonal density. In such cultures, cell-cell interactions between two different clones are eliminated and the extracellular environment is kept constant, allowing us to study the cell-intrinsic potential...

...Harry G. Leitch; Kate Blair; William Mansfield; Harold Ayetey; Peter Humphreys; Jennifer Nichols; M. Azim Surani; Austin Smith Mouse and rat embryonic stem cells can be sustained in defined medium by dual inhibition (2i) of the mitogen-activated protein kinase (Erk1/2) cascade and of glycogen...

...-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J. Cell Biol. 143 , 1385 -1398. Schwab, M. E. and Schnell, L. ( 1989 ). Region-specific appearance of myelin constituents in the developing rat...

... embryonic laminins and netrins. Curr. Opin. Cell Biol. 16 , 572 -579. * Author for correspondence (e-mail: timothy.kennedy@mcgill.ca ) 28 6 2008 © 2008. 2008 Axon guidance DCC ROCK PRK C3 Y27632 Regeneration Growth cone Rho GTPases Rat During development...

... mesencephalic ventral midline cells generate mesDA neurons, but caudal FP cells do not differentiate into neurons in vitro. ( A )HuC/D + neurons are generated from E13.5 rat mesencephalic Corin + cells, but not from metencephalic Corin + cells at 6 DIV. ( B ) Neurons generated in mesencephalic Corin + cell...

... Dystroglycan Oligodendrocyte Laminin Myelin Integrin DRG Rat Extrinsic regulatory molecules, such as growth factors, are important for oligodendrocyte development during central nervous system (CNS) myelination. Although less is known about the extrinsic regulation of oligodendrocyte development...

... of cholangiocyte marker-positive fetal liver epithelial cells (CMP-FLEC). Differentiation potential was evaluated by injecting cell isolates from dipeptidyl peptidase IV (DPPIV) positive (DPPIV+) Fischer donor rats into the spleen of partially hepatectomized, DPPIV negative (DPPIV-)Fischer host rats exposed...

...Yong Zhan; Akihiro Fujino; David T. MacLaughlin; Thomas F. Manganaro; Paul P. Szotek; Nelson A. Arango; Jose Teixeira; Patricia K. Donahoe Examination of Müllerian inhibiting substance (MIS) signaling in the rat in vivo and in vitro revealed novel developmental stage- and tissue-specific events...