... are functionally related to scribble , contribute to repress the Ras-MAPK signaling cascade in epithelia. Hence, our work uncovers novel cooperative interactions between all these well-conserved tumor suppressors that ensure tight regulation of the Ras signaling pathway. In the larval central brain...

... suppressors of ras (KSR-1/2). KSR proteins act as scaffolds facilitating Ras signaling events by tethering signaling components, and we suggest that NDK-1 modulates KSR activity through direct physical interaction. Our study reveals that C. elegans NDK-1/Nm23 influences differentiation by enhancing the level...

... signaling in the induced cells, resulting in the activation of Ets transcription factor Pointed P2. We describe developmental roles of a novel negative regulator of Ras signaling, EDL/MAE, a protein with an Ets-specific Pointed domain but not an ETS DNA-binding domain. The loss of EDL/MAE function results...

...-up: its role in the decisions mediated by the ras signaling pathway . Development 121 , 1361 – 1372 . 10.1242/dev.121.5.1361 Kretzschmar , D. , Brunner , A. , Wiersdorff , V. , Pflugfelder , G. O. , Heisenberg , M. and Schneuwly , S. ( 1992 ). Giant lens...

...Julin N. Maloof; Cynthia Kenyon ABSTRACT The Ras signaling pathway specifies a variety of cell fates in many organisms. However, little is known about the genes that function downstream of the conserved signaling cassette, or what imparts the specificity necessary to cause Ras activation to trigger...