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Keywords: Ras
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Journal Articles
Journal: Development
Development (2018) 145 (22): dev162156.
Published: 12 November 2018
... to identify deubiquitylating enzymes that modulate Ras V12 -induced hyperplastic growth. We identified the spliceosome core component Prp8 as a crucial regulator of Ras-, EGFR-, Notch- or RET-driven hyperplasia. Loss of prp8 function alone decreased cell proliferation, increased cell death, and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 623–634.
Published: 15 February 2016
... on opposed changes of junction tensions in the clone bulk and its boundary with neighboring wt tissue. More generally, either clone bulk or boundary junction tension is modulated by the activation of Yorkie, Myc and Ras, yielding similar contact reductions with wt cells. Together, our data highlight...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4279–4284.
Published: 15 November 2014
...Jean M. Parry; Meera V. Sundaram Receptor tyrosine kinase (RTK) signaling through Ras influences many aspects of normal cell behavior, including epithelial-to-mesenchymal transition, and aberrant signaling promotes both tumorigenesis and metastasis. Although many such effects are cell-autonomous...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2711–2723.
Published: 01 July 2013
... the optic nerve. Genetic evidence further supports that the formation of an Frs2α-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling in this process, whereas constitutively active Ras signaling can rescue ocular coloboma in the FGF signaling mutants. Our results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2354–2364.
Published: 01 June 2013
... developmental pathways involved in oncogenesis. We hypothesized that operative pathways during embryogenesis would also be used for oncogenesis. In an effort to define RAS target genes during embryogenesis, gene expression was evaluated in Tg(hsp70-HRAS G12V ) zebrafish embryos subjected to heat shock. dusp6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1645–1654.
Published: 15 April 2013
... to enter meiosis. Here, we show that the suppression of RAS/MAP kinase signalling in the mitotic and meiotic-entry regions is essential for the regulation of the mitosis-meiosis switch by niche signalling. We provide evidence that the conserved PUF family RNA-binding protein PUF-8 and the RAS GAP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4649–4660.
Published: 01 November 2011
... hermaphrodite, the EGFR/RAS/MAPK signaling pathway activates, together with LIN-39 HOX, the expression of VAB-23 in the primary cell lineage to control the formation of the seven vulval toroids. VAB-23 regulates the formation of homotypic contacts between contralateral pairs of cells with the same sub-fates at...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3545–3555.
Published: 15 August 2011
... that require signaling are poorly understood. Here we describe sequential roles for Notch and Epidermal growth factor (EGF)-Ras-ERK signaling in the development of epithelial tube cells in the C. elegans excretory (renal-like) organ. This simple organ consists of three tandemly connected unicellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1085–1093.
Published: 01 April 2010
... disrupted ERK signaling and cell cycle regulation, which could be partially compensated by activated Kras signaling, confirming that Ras signaling was the main downstream target of Shp2 in lens and lacrimal gland development. We also showed that Sprouty2, a general suppressor of Ras signaling, was regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (6): 1003–1013.
Published: 15 March 2010
...Taeko Ichise; Nobuaki Yoshida; Hirotake Ichise Mammalian Ras, which is encoded by three independent genes, has been thought to be a versatile component of intracellular signalling. However, when, where and how Ras signalling plays essential roles in development and whether the three Ras genes have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2695–2704.
Published: 15 July 2006
... the multivulva phenotype caused by overactivation of the Ras pathway. Our data suggest that a NURF-like complex promotes the expression of vulval cell fates by antagonizing the transcriptional and chromatin-remodeling activities of complexes similar to Myb-MuvB/dREAM, NuRD and Tip60/NuA4. Because the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 43–51.
Published: 01 January 2006
... that this cytoplasmic hold is required for vein cell fate. At the same time, we show that MAPK does move into the nucleus of other wing cells where it promotes cell proliferation. We propose a novel Ras pathway bifurcation in Drosophila and our results suggest a mechanism by which MAPK phosphorylation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (22): 5081–5092.
Published: 15 November 2005
...Daniel D. Shaye; Iva Greenwald A novel mode of crosstalk between the EGFR-Ras-MAPK and LIN-12/Notch pathways occurs during the patterning of a row of vulval precursor cells(VPCs) in Caenorhabditis elegans : activation of the EGFR-Ras-MAPK pathway in the central VPC promotes endocytosis and...
Journal Articles
Journal: Development
Development (2004) 131 (17): 4275–4285.
Published: 01 September 2004
... signal in tectal and cerebellar development, and in this report we have concentrated on the Ras-ERK pathway. In normal embryos,extracellular-signal-regulated kinase (ERK) is activated at the site where Fgf8 mRNA is expressed. Fgf8b activated ERK while Fgf8a or a lower dose of Fgf8b did not activate ERK...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2567–2577.
Published: 15 June 2003
...Gopal Battu; Erika Froehli Hoier; Alex Hajnal In C. elegans , the RAS/MAPK pathway is used in different tissues to regulate various cell fate decisions. Several positive and negative regulators tightly control the activity of the RAS/MAPK pathway at different steps. We demonstrate a link between a...
Journal Articles
Journal: Development
Development (2003) 130 (1): 57–69.
Published: 01 January 2003
...Nadeem Moghal; Paul W. Sternberg Negative regulation of receptor tyrosine kinase (RTK)/RAS signaling pathways is important for normal development and the prevention of disease in humans. We have used a genetic screen in C. elegans to identify genes that antagonize the activity of activated LET-23...
Journal Articles
Journal: Development
Development (2002) 129 (9): 2209–2222.
Published: 01 May 2002
...Karen E. James; Jennie B. Dorman; Celeste A. Berg In Drosophila melanogaster , the Ras signal transduction pathway is the primary effector of receptor tyrosine kinases, which govern diverse developmental programs. During oogenesis, epidermal growth factor receptor signaling through the Ras pathway...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5051–5060.
Published: 15 December 2001
... patterning in the optic neuroepithelium. Ectopic expression of FGF9 in the proximal region of the optic vesicle extends neural differentiation into the presumptive retinal pigment epithelium, resulting in a duplicate neural retina in transgenic mice. Ectopic expression of constitutively active Ras is also...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4153–4164.
Published: 01 November 2001
... important role in induction and patterning of the telencephalon. However, the precise role of Fgf signalling is still unclear, owing to overlapping functions of Fgf family genes. To address this, we have examined, in zebrafish embryos, the activation of Ras/mitogen-activated protein kinase (MAPK), one of...
Journal Articles
Journal: Development
Development (2001) 128 (16): 3095–3104.
Published: 15 August 2001
... transcription of genes in evolutionarily conserved signaling pathways. We showed that med-6 is involved in the transcription of genes of the Ras pathway by showing that med -6 RNAi suppressed phenotypes associated with gain-of-function alleles of let-23 and let-60 , and enhanced those associated with a...