.... Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Highlighted Article: The depletion of raptor or rictor in embryonic muscle progenitors and adult muscle stem cells shows that loss of mTORC1, but not mTORC2, signaling strongly affects, but does...

...) is an evolutionarily conserved mechanism that controls cellular growth. Here we report that mTORC1 signaling is activated during limb cartilage development in the mouse embryo. Disruption of mTORC1 signaling through deletion of either mTOR or the associated protein Raptor greatly diminishes embryonic skeletal growth...

...Kailiang Jia; Di Chen; Donald L. Riddle The highly conserved target-of-rapamycin (TOR) protein kinases control cell growth in response to nutrients and growth factors. In mammals, TOR has been shown to interact with raptor to relay nutrient signals to downstream translation machinery. We report...