... the extension of Rac-dependent protrusions, suggesting changes in the activity of FGF controlling Rac activity, switching to lamellipodium-driven migration. Inhibitors of ROCK, myosin and actin reduced the height of both early and later fibers, indicating that elongation of these fibers relies on actomyosin...

...Takashi Nakamura; Takehiko Ueyama; Yuzuru Ninoyu; Hirofumi Sakaguchi; Narantsog Choijookhuu; Yoshitaka Hishikawa; Hiroshi Kiyonari; Masaaki Kohta; Mizuho Sakahara; Ivan de Curtis; Eiji Kohmura; Yasuo Hisa; Atsu Aiba; Naoaki Saito Rac signaling impacts a relatively large number of downstream targets...

... stimulates Abl kinase activity. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase: Abl gates the activity of the spectrin repeats of Trio, allowing them to relieve intramolecular repression of Trio GEF...

... microtubule catastrophe by inhibiting the Rac-GEF Trio, as double inhibition of Par3 and Trio restores microtubule catastrophe at the cell contact and rescues CIL and neural crest migration. Our results demonstrate a novel role of Par3 during neural crest migration, which is likely to be conserved in other...

...Isabelle Migeotte; Joaquim Grego-Bessa; Kathryn V. Anderson The establishment of the mammalian body plan depends on signal-regulated cell migration and adhesion, processes that are controlled by the Rho family of GTPases. Here we use a conditional allele of Rac1 , the only Rac gene expressed early...

...Lijun Zhang; Jun Luo; Ping Wan; Jing Wu; Frank Laski; Jiong Chen During Drosophila oogenesis, two actin dynamics regulators, cofilin and Rac, are required for the collective migration of a coherent cluster of cells called border cells. Cell culture data have shown that Rac and cofilin are both...

... pathway requires inhibition of PKCδ and activation of PKCα. We show that PKCα inhibits Rac GTPase and that c-Jun is a target of Rac. These findings might account for previous reports implicating PKC in neural induction and allow us to propose a link between FGF and PKC signalling pathways during neural...

...Mark Lucanic; Maureen Kiley; Neville Ashcroft; Noelle L'Etoile; Hwai-Jong Cheng P21 activated kinases (PAKs) are major downstream effectors of rac-related small GTPases that regulate various cellular processes. We have identified the new PAK gene max-2 in a screen for mutants disrupted in UNC-6...

... in exploring the extracellular surroundings with filopodia-like Actin containing projections. We hypothesized that the small GTPases Rho, Rac and Cdc42 are involved in Actin cytoskeletal rearrangements that underlie peripheral glial migration and nerve ensheathement. To test this, transgenic forms...

... of the phosphorylation of myosin regulatory light chains, or dynamic activation and inactivation of myosin II, is essential for its various functions during many developmental processes. * Author for correspondence (e-mail: [email protected] ) 21 11 2002 © 2003. 2003 Rac Rho Rho...

...Eric C. Struckhoff; Erik A. Lundquist Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role...

...Erik A. Lundquist; Peter W. Reddien; Erika Hartwieg; H. Robert Horvitz; Cornelia I. Bargmann The Caenorhabditis elegans genome contains three rac -like genes, ced-10, mig-2 , and rac-2 . We report that ced-10 , mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little...

...Vesa Kaartinen; Ignacio Gonzalez-Gomez; Jan Willem Voncken; Leena Haataja; Emmanuelle Faure; Andre Nagy; John Groffen; Nora Heisterkamp Experiments in cultured cells have implicated the molecular switch Rac in a wide variety of cellular functions. Here we demonstrate that the simultaneous...

..., with associated alterations in the actin cytoskeleton. They also provide a new perspective about the determinants of small intestinal villus morphogenesis. Rac MAP kinases Actin Mouse Intestine Epithelium *Author for correspondence (e-mail: [email protected] ) 17 4 2001 ©...

...Masaki Sone; Emiko Suzuki; Mikio Hoshino; Dongmei Hou; Hiroshi Kuromi; Masaki Fukata; Shinya Kuroda; Kozo Kaibuchi; Yo-ichi Nabeshima; Chihiro Hama ABSTRACT A cell-adhesion molecule fasciclin 2 (FAS2), which is required for synaptic growth and still life (SIF), an activator of RAC, were found...

...Nicholas Harden; Hui Yong Loh; William Chia; Louis Lim ABSTRACT The Rho subfamily of Ras-related small GTP-binding proteins is involved in regulation of the cytoskeleton. The cytoskeletal changes induced by two members of this subfamily, Rho and Rac, in response to growth factor stim-ulation, have...