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Keywords: Rac
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Journal Articles
Journal: Development
Development (2017) 144 (10): 1863–1875.
Published: 15 May 2017
...Takashi Nakamura; Takehiko Ueyama; Yuzuru Ninoyu; Hirofumi Sakaguchi; Narantsog Choijookhuu; Yoshitaka Hishikawa; Hiroshi Kiyonari; Masaaki Kohta; Mizuho Sakahara; Ivan de Curtis; Eiji Kohmura; Yasuo Hisa; Atsu Aiba; Naoaki Saito Rac signaling impacts a relatively large number of downstream targets...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 487–498.
Published: 01 February 2017
... Disabled stimulates Abl kinase activity. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase: Abl gates the activity of the spectrin repeats of Trio, allowing them to relieve intramolecular repression of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4763–4775.
Published: 01 December 2013
..., Par3 promotes microtubule catastrophe by inhibiting the Rac-GEF Trio, as double inhibition of Par3 and Trio restores microtubule catastrophe at the cell contact and rescues CIL and neural crest migration. Our results demonstrate a novel role of Par3 during neural crest migration, which is likely to be...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 3011–3020.
Published: 15 July 2011
...Isabelle Migeotte; Joaquim Grego-Bessa; Kathryn V. Anderson The establishment of the mammalian body plan depends on signal-regulated cell migration and adhesion, processes that are controlled by the Rho family of GTPases. Here we use a conditional allele of Rac1 , the only Rac gene expressed early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (3): 455–464.
Published: 01 February 2011
...Lijun Zhang; Jun Luo; Ping Wan; Jing Wu; Frank Laski; Jiong Chen During Drosophila oogenesis, two actin dynamics regulators, cofilin and Rac, are required for the collective migration of a coherent cluster of cells called border cells. Cell culture data have shown that Rac and cofilin are both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 575–584.
Published: 15 February 2009
... pathway requires inhibition of PKCδ and activation of PKCα. We show that PKCα inhibits Rac GTPase and that c-Jun is a target of Rac. These findings might account for previous reports implicating PKC in neural induction and allow us to propose a link between FGF and PKC signalling pathways during neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4549–4559.
Published: 15 November 2006
...Mark Lucanic; Maureen Kiley; Neville Ashcroft; Noelle L'Etoile; Hwai-Jong Cheng P21 activated kinases (PAKs) are major downstream effectors of rac-related small GTPases that regulate various cellular processes. We have identified the new PAK gene max-2 in a screen for mutants disrupted in UNC-6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (9): 1825–1835.
Published: 01 May 2003
... in exploring the extracellular surroundings with filopodia-like Actin containing projections. We hypothesized that the small GTPases Rho, Rac and Cdc42 are involved in Actin cytoskeletal rearrangements that underlie peripheral glial migration and nerve ensheathement. To test this, transgenic forms of...
Journal Articles
Journal: Development
Development (2003) 130 (4): 671–681.
Published: 15 February 2003
... phosphorylation of myosin regulatory light chains, or dynamic activation and inactivation of myosin II, is essential for its various functions during many developmental processes. * Author for correspondence (e-mail: perrimon@rascal.med.harvard.edu ) 21 11 2002 © 2003. 2003 Rac Rho Rho...
Journal Articles
Journal: Development
Development (2003) 130 (4): 693–704.
Published: 15 February 2003
...Eric C. Struckhoff; Erik A. Lundquist Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role of...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4475–4488.
Published: 15 November 2001
...Erik A. Lundquist; Peter W. Reddien; Erika Hartwieg; H. Robert Horvitz; Cornelia I. Bargmann The Caenorhabditis elegans genome contains three rac -like genes, ced-10, mig-2 , and rac-2 . We report that ced-10 , mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4217–4227.
Published: 01 November 2001
...Vesa Kaartinen; Ignacio Gonzalez-Gomez; Jan Willem Voncken; Leena Haataja; Emmanuelle Faure; Andre Nagy; John Groffen; Nora Heisterkamp Experiments in cultured cells have implicated the molecular switch Rac in a wide variety of cellular functions. Here we demonstrate that the simultaneous...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2603–2614.
Published: 01 July 2001
... associated alterations in the actin cytoskeleton. They also provide a new perspective about the determinants of small intestinal villus morphogenesis. *Author for correspondence (e-mail: jgordon@molecool.wustl.edu ) 17 4 2001 © 2001. 2001 Rac MAP kinases Actin Mouse Intestine...