.... Additionally, wild-type ventricular muscle cells grafted into the wild-type background appropriately downregulate MLC-2a and α-MHC. Finally, grafting of RXRα gene-deficient ventricular muscle cells into the ventricular chambers of wild-type embryos does not rescue the persistent expression of MLC-2a, providing...

...Ju Chen; Steven W. Kubalak; Kenneth R. Chien ABSTRACT Mouse embryos lacking the retinoic acid receptor gene RXRα die in midgestation from hypoplastic development of the myocardium of the ventricular chambers and consequent cardiac failure. In this study, we address the issue of whether the RXR α...