... pop-1 , support the model that POP-1 TCF induces differentiation at a high nuclear level, whereas low nuclear POP-1 promotes seam cell self-renewal. Before symmetric division, the transcriptional regulator RNT-1 Runx and cofactor BRO-1 CBFβ temporarily bypass Wnt/β-catenin asymmetry by downregulating...

...Renaud Mevel; Julia E. Draper; Michael Lie-a-Ling; Valerie Kouskoff; Georges Lacaud ABSTRACT RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce...

... and the commitment of mesenchymal cells to become chondrocytes through the induction of Sox5 and Sox6 . * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 31 1 2010 © 2010. 2010 Runx Chondrogenesis...

... for thermal and neuropathic pain. Neuron 49 , 365 -377. Coffman, J. A. ( 2003 ). Runx transcription factors and the developmental balance between cell proliferation and differentiation. Cell Biol. Int. 27 , 315 -324. Copray, J. C., Mantingh-Otter, I. J. and Brouwer, N. ( 1994 ). Expression...

... of the mammalian CBFβ-interacting Runx factors), caused by failed cell divisions in the seam lineages. Our studies indicate that BRO-1 and RNT-1 form a cell proliferation-promoting complex, and that BRO-1 increases both the affinity and specificity of RNT-1-DNA interactions. Overexpression of bro-1 ,like rnt-1...

... (GCM) and GCM2 control plasmatocyte development, whereas the RUNX factor Lozenge (LZ) is required for crystal cell differentiation. We have investigated the segregation process that leads to the formation of these two cell types, and the interplay between LZ and GCM/GCM2. We show that,surprisingly, gcm...

... rules for slp1 regulation make this an attractive target for dissecting the molecular mechanisms of Runt-dependent regulation. * Author for correspondence (e-mail: [email protected] ) 3 2 2003 © 2004. 2004 Runx Hox Zic Segmentation sloppy paired 1 engrailed...

.... and Rubin, G. M. ( 1994 ). Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Ann. Rev.Neurosci . 17 , 373 -397. Big brother Brother lozenge runt Runx Eye development Ommatidium CBFβ RNAi A fundamental problem in biology is determining how...