... metabolism intersects with these processes. Chicken embryos can regenerate their retina through retinal pigment epithelium (RPE) reprogramming when treated with fibroblast factor 2 (FGF2). Using transcriptome profiling, we uncovered extensive regulation of gene sets pertaining to proliferation, neurogenesis...

... lineages. Here, we define this regulatory interplay in the developing retinal pigmented epithelium (RPE), a neuroectodermal lineage essential for the development, function and maintenance of the adjacent retina. We present a high-resolution spatial transcriptomic atlas of the developing mouse RPE...

...Reut Ohana; Benjamin Weiman-Kelman; Shaul Raviv; Ernst R. Tamm; Metsada Pasmanik-Chor; Ariel Rinon; Dvir Netanely; Ron Shamir; Arie S. Solomon; Ruth Ashery-Padan Dysfunction of the retinal pigmented epithelium (RPE) results in degeneration of photoreceptors and vision loss and is correlated...

...Peter Westenskow; Stefano Piccolo; Sabine Fuhrmann The retinal pigment epithelium (RPE) consists of a monolayer of cuboidal,pigmented cells that is located between the retina and the choroid. The RPE is vital for growth and function of the vertebrate eye and improper development results...

... pigment epithelium (RPE). We find that a Wnt reporter transgene and Wnt pathway components are expressed in the dorsal RPE beginning at 14-16 hours post-fertilization. In the absence of Wnt signaling, tbx5 and Bmp genes initiate normal dorsal retinal expression but are not maintained. The expression...

... called Shroom),is sufficient to induce a dramatic apical accumulation of the microtubule-nucleating protein γ-tubulin at the apical surfaces of naïve epithelial cells. Together, our data identify Shroom2 as a central regulator of RPE pigmentation, and suggest that, despite their diverse biological roles...

... (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation. Mitf mutants have a dorsal RPE-to-neuroretinal phenotypic transformation, indicating that Mitf is a determinant of RPE identity. We report here that Mitf...

... epithelium to signal properly to the retina. * Author for correspondence (e-mail: [email protected] ) 17 10 2000 27 11 2000 © 2001 by Company of Biologists 2001 Cell fate determination Danio rerio Eye Mutation Polarity Proliferation RPE Two major...