... of Biologists Ltd 2024 Summary: Deleting Phf5a in B cells reveals its essential role in IgH chain V-to-DJ gene rearrangement via modulating RAG activity and chromatin interaction at the IgH locus in a spliceosome-dependent manner. Phf5a RNA splicing VDJ gene recombination B cell development...

... maintenance and meristem activity. One level of gene regulation is RNA alternative splicing. However, the mechanistic link between stress, meristem function and RNA splicing is poorly understood. The MERISTEM-DEFECTIVE ( MDF ) Arabidopsis gene encodes an SR-related family protein, required for meristem...

... for survival and progression. We show that the pioneer transcription factors Foxa1 and Foxa2 are required to regulate RNA splicing during positive selection of mouse T cells and that Foxa1 and Foxa2 have overlapping/compensatory roles. Conditional deletion of both Foxa1 and Foxa2 from DP thymocytes reduced...

.../ Summary: Ddx39ab is required for pre-mRNA splicing of KMT2 histone methyltransferases, with ddx39ab mutants failing to establish the epigenetic status required for terminal differentiation of cardiomyocyte, myoblast and lens fiber cell lineages. RNA helicase Myocyte Lens RNA splicing...

... to the increased primary U1/U2 snRNAs,the level of mature U1/U2 snRNAs was not significantly altered in ints5 morphants (see Fig. S6E,F in the supplementary material ). These results show that Ints5 regulation of smad1/5 RNA splicing is mediated via U1/U2 snRNA processing. To determine the epistatic...

... and thereby imposing the productive (female) splicing mode. The gene splicing-necessary factor ( snf ), which encodes a component of U1 and U2 snRNPs, participates in this RNA splicing control. Here we show that an increase in the dose of snf + can trigger the female Sx1 RNA splicing mode in male germ cells...

... Marseille-Luminy, 13288 Marseille, Cedex 9, France 26 07 1993 © 1993 by Company of Biologists 1993 Drosophila ovarian tumors RNA splicing germ-line sex determination A fundamental biological choice in many organisms is the decision to make eggs or sperm. Control...