...Si Chen; Kira L. Lathrop; Takaaki Kuwajima; Jeffrey M. Gross ABSTRACT Visual information is transmitted from the eye to the brain along the optic nerve, a structure composed of retinal ganglion cell (RGC) axons. The optic nerve is highly vulnerable to damage in neurodegenerative diseases...

...Maurício Rocha-Martins; Beatriz C. de Toledo; Pedro L. Santos-França; Viviane M. Oliveira-Valença; Carlos H. Vieira-Vieira; Gabriel E. Matos-Rodrigues; Rafael Linden; Caren Norden; Rodrigo A. P. Martins; Mariana S. Silveira ABSTRACT Retinal ganglion cell (RGC) degeneration is a hallmark of glaucoma...

...Pooja Teotia; Matthew J. Van Hook; Dietmar Fischer; Iqbal Ahmad ABSTRACT The poor axon regeneration in the central nervous system (CNS) often leads to permanent functional deficit following disease or injury. For example, degeneration of retinal ganglion cell (RGC) axons in glaucoma leads...

...-expressed with BRN3B, a POU-HD factor, in nascent post-mitotic retinal ganglion cells (RGCs). Similar to the Brn3b -null retinas, retina-specific deletion of Isl1 results in the apoptosis of a majority of RGCs and in RGC axon guidance defects. The Isl1 and Brn3b double null mice display more severe retinal...