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Keywords: RET
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Journal Articles
Journal: Development
Development (2024) 151 (24): dev203012.
Published: 18 December 2024
...Nicole E. Franks; Benjamin L. Allen ABSTRACT Growth arrest specific 1 (GAS1) is a key regulator of mammalian embryogenesis, best known for its role in hedgehog (HH) signaling, but with additional described roles in the FGF, RET, and NOTCH pathways. Previous work indicated a later role for GAS1...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (16): dev197020.
Published: 12 August 2021
... that Lrig1 acts through this mechanism to inhibit Ret activity. However, it is unclear whether other Lrig family members play similar roles. Here, we show that Lrig1 and Lrig3 are co-expressed in Ret-positive mouse dorsal root ganglion (DRG) neurons. Lrig3, like Lrig1, interacts with Ret and inhibits GDNF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2282–2293.
Published: 15 June 2017
... of the prostatic epithelium. However, the nature of the AR-regulated morphogenetic genes and the mechanisms whereby AR controls prostate development are not understood. Glial cell line-derived neurotrophic factor (GDNF) binds GDNF family receptor α1 (GFRα1) and signals through activation of RET tyrosine kinase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2696–2703.
Published: 1 August 2015
... indicates that both genes play partially redundant roles in ureterovesical junction formation. Aspects of the Yap −/− phenotype resemble hypersensitivity to RET signaling, including excess budding of the ND, increased phospho-ERK and increased expression of Crlf1 , Sprouty1 , Etv4 and Etv5 . Importantly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2405–2415.
Published: 1 July 2012
...Masato Hoshi; Ekatherina Batourina; Cathy Mendelsohn; Sanjay Jain Mutations in the receptor tyrosine kinase RET are associated with congenital anomalies of kidneys or urinary tract (CAKUT). RET tyrosine Y1015 is the docking site for PLCγ, a major regulator of RET signaling. Abrogating signaling via...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3007–3011.
Published: 15 September 2008
... and colonises the entire gastrointestinal tract to form the enteric nervous system(ENS). The colonisation of embryonic gut by NCCs has been studied extensively in chick embryos, and genetic studies in mice have identified genes crucial for ENS development, including Ret . Here, we have combined mouse embryo...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (1): 241–249.
Published: 1 January 2004
... along its length. Both gfra1a and gfra1b as well as ret are expressed at this time, while gfra2 expression, the receptor component that binds the GDNF-related ligand neurturin, is not detected until the precursors have migrated along the gut. Gfra genes are also expressed in regions of the zebrafish...
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (10): 2187–2198.
Published: 15 May 2003
...Scott Gianino; John R. Grider; Jennifer Cresswell; Hideki Enomoto; Robert O. Heuckeroth To clarify the role of Ret signaling components in enteric nervous system(ENS) development, we evaluated ENS anatomy and intestinal contractility in mice heterozygous for Ret, GFRα1 and Ret ligands...
Journal Articles
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Journal Articles
Journal: Development
Development (2001) 128 (19): 3773–3782.
Published: 1 October 2001
... at early embryonic ages almost entirely suppresses ciliary axon outgrowth. These results demonstrate that target-derived GDNF is necessary for ciliary ganglion neurons to innervate ciliary muscle in the eye. Since the down-regulation of GDNF in the eye is accompanied by down-regulation of GFRα1 and Ret...
Journal Articles
Journal: Development
Development (2000) 127 (20): 4383–4393.
Published: 15 October 2000
... from a mitogenic to a trophic response by the developing enteric neurons. The timing of this shift corresponded to developmental changes in gut expression of GFRα-1, a co-receptor in the GDNF-Ret signaling complex. GFRα-1 was broadly expressed in the gut at early developmental stages, at which times...
Journal Articles
Journal Articles