... enzymes, such as cytochrome P450 26 (Cyp26 genes). Here, we show that RDH10 is important for both sensory and non-sensory formation of the vestibule of the inner ear. Mice deficient in Rdh10 exhibit failure of utricle-saccule separation, otoconial formation and zonal patterning of vestibular sensory...

... are very poorly defined. We identified RDH10 , a gene crucial for retinoic acid synthesis during embryogenesis, as a key factor downregulated in the peripheral retina (presumptive ciliary body region) of lens-removed embryonic chicken eyes prior to overt reductions in eye size. This is associated...

... show that retinoic acid (RA) signaling activity at the site of gland initiation is colocalized with expression of retinol metabolic genes Rdh10 and Aldh1a2 in the underlying SMG mesenchyme. Utilizing a novel ex vivo assay for SMG initiation developed for this study, we show that RDH10 and RA...

... on the specific expression characteristics and on cooperation between RDH10 and RALDH2 ( Fig. 9 ). The microsomal RDH10 enzyme in the anterior trunk mesoderm produces and secretes retinal that diffuses into posterior cells, where RALDH2 converts it into RA. The combinatorial mRNA distribution of RDH10...