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Keywords: Quiescence
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Journal Articles
Journal: Development
Development (2021) 148 (20): dev199629.
Published: 19 October 2021
... with control or Cre-adenovirus following 72 h quiescence induction and samples were collected 2, 5 and 6 days later. (F) YFP, EdU, Ki67 and DAPI immunolabelling 2, 5 and 8 days after control- and Cre-adenovirus transduction in control and β-cat del ex3-6 quiescent NSCs. (G) Quantification of the proportion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev194571.
Published: 30 April 2021
... of quiescence is known to occur in prospermatogonia prior to postnatal spermatogonial transition, the importance of this has not been defined. Here, using mouse models with conditional knockout of the master cell cycle regulator Rb1 to disrupt normal timing of the quiescence period, we found that failure...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev162636.
Published: 26 November 2018
... Chakkalakal , J. V. , Jones , K. M. , Basson , M. A. and Brack , A. S. ( 2012 ). The aged niche disrupts muscle stem cell quiescence . Nature   490 , 355 - 360 . 10.1038/nature11438 Cormier , S. , Le Bras , S. , Souilhol , C. , Vandormael-Pournin , S. , Durand , B...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev161034.
Published: 15 May 2018
... properties are linked, and to what extent they can be independently controlled by NSC maintenance pathways, is unresolved. We have previously identified Notch3 signalling as a major quiescence-promoting pathway in adult NSCs of the zebrafish pallium. We now show that Notch3 also controls NSC stemness. Using...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2017) 144 (9): 1619–1628.
Published: 01 May 2017
... and plays a crucial role in BR-mediated control of organ boundary formation in the shoot and cell division in the root. BR signaling BES1 EAR domain TOPLESS Organ boundary Quiescent center Quiescence Brassinosteroids (BRs) are steroid plant hormones with an essential role in plant growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 962–971.
Published: 15 March 2016
... was reduced by 50% in H19 Δ 3 muscle fibers. This reduction occurred after postnatal day 21, suggesting a link with their entry into quiescence. We investigated the biological function of these mutant satellite cells in vivo using a regeneration assay induced by multiple injections of cardiotoxin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 3033–3045.
Published: 01 September 2015
...Dan Sun; Laura Buttitta Protein phosphatase type 2A complex (PP2A) has been known as a tumor suppressor for over two decades, but it remains unclear exactly how it suppresses tumor growth. Here, we provide data indicating a novel role for PP2A in promoting the transition to quiescence upon terminal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2740–2751.
Published: 15 August 2015
... to tissue damage in the developing Drosophila eye. Drosophila Cell cycle Quiescence Apoptosis Compensatory proliferation Regeneration Hippo signaling Tissue regeneration has fascinated biologists for many years, but the molecular mechanisms underlying this process have only recently...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1572–1581.
Published: 01 May 2015
... and intrinsic regulatory mechanisms. Satellite cell Muscle stem cell Myogenesis Quiescence Cell cycle regulation Asymmetric division Self-renewal Skeletal muscle Regeneration Aging Whether the defects in the regenerative capacity of aged muscle are caused by changes in the satellite...
Journal Articles
Journal: Development
Development (2014) 141 (24): 4656–4666.
Published: 15 December 2014
...Ayako Nakamura-Ishizu; Hitoshi Takizawa; Toshio Suda Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of efficient self-renewal and differentiation; some of these have been shown to exist in a dormant, or quiescent, cell cycle state. Such quiescence has been...
Journal Articles
Journal: Development
Development (2014) 141 (12): 2402–2413.
Published: 15 June 2014
... The ability of adult stem cells to reside in a quiescent state is crucial for preventing premature exhaustion of the stem cell pool. However, the intrinsic epigenetic factors that regulate spermatogonial stem cell quiescence are largely unknown. Here, we investigate in mice how DNA methyltransferase 3-like...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1649–1659.
Published: 15 April 2014
... Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Muscle Quiescence Regeneration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3335–3347.
Published: 15 August 2013
... quiescence and increased occurrence of symmetric divisions. Expression analyses, morpholino-mediated invalidation and the generation of a notch3 -null mutant directly implicate Notch3 in these effects. By contrast, abrogation of notch1b function results in the generation of neurons at the expense...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1445–1456.
Published: 01 April 2013
... progenitor characteristics of nascent Müller glia - their radial morphology and cell cycle quiescence - are disrupted following conditional genetic ablation of Sox2 in the mouse postnatal retina, leading to Müller cell depletion and retinal degeneration. Moreover, we demonstrate that genetic induction...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 2857–2865.
Published: 15 August 2012
... that maintain the homeostasis and mediate the regeneration of skeletal muscles. We demonstrate here that hypoxic culture conditions favor the quiescence of satellite cell-derived primary myoblasts by upregulating Pax7, a key regulator of satellite cell self-renewal, and downregulating MyoD and myogenin. During...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (12): 2177–2186.
Published: 15 June 2012
... a quiescence-induced shift in the repertoire of microRNAs that regulate HBL-1. During continuous development, HBL-1 downregulation (and consequent cell fate progression) relies chiefly on three let-7 family microRNAs, whereas after quiescence, HBL-1 is downregulated primarily by the lin-4 microRNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (23): 3859–3869.
Published: 01 December 2008
...Takuya Tsuji; Eri Hasegawa; Takako Isshiki Neural stem cell quiescence is an important feature in invertebrate and mammalian central nervous system development, yet little is known about the mechanisms regulating entry into quiescence, maintenance of cell fate during quiescence, and exit from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (16): 2739–2746.
Published: 15 August 2008
... Polarity Quiescence Drosophila Drosophila larval brain neural progenitors (neuroblasts) are a powerful system with which to study the role of asymmetric cell division and stem cell self-renewal and proliferation. aPKC is required for both cell polarity and stem cell self-renewal...