...Tsubasa Itoh; Mari Uehara; Shinnosuke Yura; Jui Chun Wang; Yukimi Fujii; Akiko Nakanishi; Takashi Shimizu; Masahiko Hibi ABSTRACT Cerebellar neurons, such as GABAergic Purkinje cells (PCs), interneurons (INs) and glutamatergic granule cells (GCs) are differentiated from neural progenitors...

... nuclei] and the spinal cord (via mossy fibers) is collected in the cerebellar cortex by the Purkinje cells (PC) and communicated to the cerebellar output neurons in the cerebellar nuclei (CN) that reside in the white matter. A, anterior; GC, granule cell; GoC, Golgi cell; L, lateral; M, medial; P...

... intrinsic to most cell types. Here, we prove its suitability in vivo by monitoring the ablation of cerebellar Purkinje cells (PCs) in transgenic zebrafish that co-express the inducible caspase and a fluorescent reporter. Incubation of larvae in tamoxifen for 8 h activated endogenous Caspase 3 and cell death...

.... Such transcriptional changes lead to increased GABAergic interneurons and decreased Purkinje cells. Transcriptional changes also inhibit the proliferation of granule precursor cells derived from the rhombic lip. The loss of both cell types ultimately results in cerebellar hypoplasia. These findings indicate Ezh2/PRC2...

... ) * Present address: Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany Competing interests statement The authors declare no competing financial interests. 18 4 2012 © 2012. Neurog2 Ngn2 Purkinje cells Cell cycle Cerebellum Dendrite...

.... This part of the brain has a relatively simple structure and contains well-characterized cell populations. We found that Wnt -3 is expressed during development of the cerebellum and that expression is restricted to the Purkinje cell layer in the adult. Wnt -3 expression in Purkinje cells increases...