... sequenced and annotated (and others now have preliminary assemblies). Searches of all five genomes revealed two PUF protein families not present in this earlier analysis: PUF-12 and PUF-13. The functions of these two newly added PUF subfamilies are unknown. Phylogenetic reconstruction unambiguously groups...

... involves regulatory molecules that also operate as translational repressors, such as members of PUF proteins. In this study, we identified a homologue of the Drosophila PUF gene Pumilio ( DjPum ) in the planarian Dugesia japonica , with an expression pattern preferentially restricted to neoblasts. Through...

...Chiara Gamberi; David S. Peterson; Luming He; Ellen Gottlieb Bicoid is a key determinant of anterior Drosophila development. We demonstrate that the prototypical Puf protein Pumilio temporally regulates bicoid ( bcd ) mRNA translation via evolutionarily conserved Nanos response elements (NRE...