1-11 of 11
Keywords: Ptf1a
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (19): dev190603.
Published: 9 October 2020
... are derived from neural progenitors expressing the proneural gene ptf1a . In this study, we found that the homeobox gene gsx2 was co-expressed with ptf1a in IO progenitors in zebrafish. Both gsx2 and ptf1a zebrafish mutants showed a strong reduction or loss of IO neurons. The expression of ptf1a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev164913.
Published: 27 June 2019
... systems, Dre/RoxP and Cre/LoxP, to independently trace green fluorescent Pdx1-lineage cells and red fluorescent Ptf1a-lineage cells in the developing and adult mouse pancreas. We detected a few Pdx1 + /Ptf1a − lineage cells in addition to the vast majority of Pdx1 + /Ptf1a + lineage cells in the pancreas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4385–4394.
Published: 15 November 2014
... of a presumed pancreatic-commitment transcription factor, Ptf1a, in embryonic mouse endoderm (Ptf1a EDD ) dramatically expanded the pancreatic gene regulatory network within the foregut. Ptf1a EDD temporarily suppressed Sox2 broadly over the anterior endoderm. Pancreas-proximal organ territories underwent full...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4031–4041.
Published: 1 November 2014
... interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Granule cell Atoh1 Autistic spectrum disorder Medulloblastoma Ptf1a Purkinje cell The cerebellum (‘little brain’) resides at the anterior end of the hindbrain...
Journal Articles
Journal: Development
Development (2014) 141 (14): 2803–2812.
Published: 15 July 2014
...-helix transcription factors (TFs), Ascl1 and Ptf1a, have contrasting functions in specifying these neurons. To understand how Ascl1 and Ptf1a function in this process, we identified their direct transcriptional targets genome-wide in the embryonic mouse neural tube using ChIP-Seq and RNA-Seq. We show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1744–1753.
Published: 15 May 2012
... to the availability of RBP-jκ to engage in Ptf1a–RBP-jκ complex formation, as opposed to its availability for forming RBP-jκ–NICD complexes at Notch target promoters in Psen1/2 -competent cells ( Cras-Meneur et al., 2009 ). Although a stoichiometric argument of limiting availability of RBP-jκ is intriguing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 33–45.
Published: 1 January 2012
... and thereby represses Neurog3 and endocrine differentiation in neighboring cells by lateral inhibition. Here we show in mouse that Dll1 and Hes1 expression deviate during regionalization of early endoderm, and later during early pancreas morphogenesis. At that time, Ptf1a activates Dll1 in multipotent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (22): 4011–4021.
Published: 15 November 2007
... upon SU5402 treatment ( Fig. 3C ),whereas only a weak reduction of trypsin was observed in the fgf24 morphants and mutants. None of the double fgf10/fgf24 morphant embryos exhibited ptf1a expression at 36 hpf( Fig. 7C ). The delayed ptf1a expression observed at 50 hpf in the fgf24 mutants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (6): 1151–1160.
Published: 15 March 2007
... expressions, which are influenced by pattern formation and cell-specification pathways. We report here that the tissue-specific bHLH transcription factor Ptf1a (also known as PTF1-p48 ) is expressed from embryonic day 12.5 of gestation (E12.5)to postnatal day 3 (P3) during retinogenesis in the mouse. Using...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4439–4450.
Published: 15 November 2006
... and one class of glial cells, all derived from a population of multipotent progenitors. There is little information on the molecular mechanisms governing the specification of cell type identity from multipotent progenitors in the developing retina. We report that Ptf1a, a basic-helix-loop-helix (bHLH...
Journal Articles
Journal: Development
Development (2004) 131 (4): 807–817.
Published: 15 February 2004
... does not require aorta or endothelial cell interactions, but dorsal pancreatic bud emergence and the maintenance of Pdx1 expression does. Aortal endothelial cells induce the crucial pancreatic transcription factor Ptf1a in the dorsal pancreatic endoderm; whereas the vitelline veins, which are normally...