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Keywords: Psoriasis
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Journal Articles
Rob van der Kammen, Ji-Ying Song, Iris de Rink, Hans Janssen, Stefania Madonna, Claudia Scarponi, Cristina Albanesi, Wim Brugman, Metello Innocenti
Journal:
Development
Development (2017) 144 (24): 4588–4603.
Published: 15 December 2017
.... Here, we employed conditional A rpc4 knockout mice to study the function of the Arp2/3 complex in the epidermis. We found that depletion of the Arp2/3 complex by knockout of Arpc4 results in skin abnormalities at birth that evolve into a severe psoriasis-like disease hallmarked by hyperactivation...
Includes: Supplementary data
