...Menglong Rui; Shufeng Bu; Liang Yuh Chew; Qiwei Wang; Fengwei Yu ABSTRACT Neuronal pruning is essential for proper wiring of the nervous systems in invertebrates and vertebrates. Drosophila ddaC sensory neurons selectively prune their larval dendrites to sculpt the nervous system during early...

... attributed. Summary: Genetic deficiency of Npc1 impairs postnatal development of microglia and climbing fiber synaptic pruning in the mouse cerebellum. Cerebellum CLEC7A NPC VGLUT2 Microglia Pruning Niemann–Pick disease type C (NPC) is a recessive genetic lysosomal storage...

...Qiwei Wang; Yan Wang; Fengwei Yu ABSTRACT Pruning that selectively removes unnecessary neurites without causing neuronal death is essential for sculpting the mature nervous system during development. In Drosophila , ddaC sensory neurons specifically prune their larval dendrites with intact axons...

...Svende Herzmann; Ina Götzelmann; Lea-Franziska Reekers; Sebastian Rumpf ABSTRACT Large-scale neurite pruning is an important specificity mechanism during neuronal morphogenesis. Drosophila sensory neurons prune their larval dendrites during metamorphosis. Pruning dendrites are severed...

...Yan Wang; Heng Zhang; Meng Shi; Yih-Cherng Liou; Lei Lu; Fengwei Yu Pruning, whereby neurons eliminate their excess neurites, is central for the maturation of the nervous system. In Drosophila , sensory neurons, ddaCs, selectively prune their larval dendrites without affecting their axons during...

...Charles Betz; Anna Lenard; Heinz-Georg Belting; Markus Affolter Vascular networks are formed and maintained through a multitude of angiogenic processes, such as sprouting, anastomosis and pruning. Only recently has it become possible to study the behavior of the endothelial cells that contribute...

...Sebastian Rumpf; Sung Bae Lee; Lily Yeh Jan; Yuh Nung Jan The regulated degeneration of axons or dendrites (pruning) and neuronal apoptosis are widely used during development to determine the specificity of neuronal connections. Pruning and apoptosis often share similar mechanisms; for example...

... neuronal structure, several previously examined instances of developmental pruning were unaffected by WD pathways. We used laser axotomy and time-lapse confocal imaging to characterize and compare peripheral sensory axon WD and developmental pruning in live zebrafish larvae. Detached fragments of single...

..., followed by thinning of the disrupted region, severing and fragmentation. Retraction was observed at distal tips of branches and in proximal stumps after severing events. The pruning program of da neuron dendrites is steroid induced; cell-autonomous dominant-negative inhibition of steroid action blocks...

.... Developmental studies indicate that these neurons undergo stereotyped pruning of their dendrites and axon terminal branches locally during early metamorphosis. Electron microscopy analysis reveals that these PNs synapse with MB γ neurons in the larval calyx and that these synaptic profiles are engulfed by glia...