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Keywords: Prox1
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Journal Articles
Journal: Development
Development (2020) 147 (23): dev195453.
Published: 13 December 2020
... factor PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs). We and others previously reported a feedback loop between PROX1 and vascular endothelial growth factor-C (VEGF-C) signaling. PROX1 promotes the expression of the VEGF-C receptor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev160184.
Published: 17 May 2018
... capillary plexus constitutes an additional, local source of LECs that contributes to the formation of the dermal lymphatic vascular network. We describe a novel mechanism whereby rare PROX1-positive endothelial cells exit the capillary plexus in a Ccbe1 -dependent manner to establish discrete LEC clusters...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1753–1765.
Published: 15 May 2016
... well-known caudal migratory stream (CMS), contribute to populate the neocortex, hippocampus and amygdala. These paths appear in a precise temporal sequence and express a distinct combination of transcription factors, such as SP8, PROX1, COUP-TFI and COUP-TFII. By inactivating COUP-TFI in developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1228–1238.
Published: 15 March 2014
...Andreas van Impel; Zhonghua Zhao; Dorien M. A. Hermkens; M. Guy Roukens; Johanna C. Fischer; Josi Peterson-Maduro; Henricus Duckers; Elke A. Ober; Philip W. Ingham; Stefan Schulte-Merker In mammals, the homeodomain transcription factor Prox1 acts as the central regulator of lymphatic cell fate. Its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 538–547.
Published: 01 February 2014
... epithelium requires the activity of the homeobox gene Prox1 . Here, we show that Prox1 is a novel regulator of cell differentiation and morphogenesis during hepatogenesis. Prox1 ablation in bipotent hepatoblasts dramatically reduced the expression of multiple hepatocyte genes and led to very defective...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2365–2376.
Published: 01 June 2013
...Aino Murtomaki; Minji K. Uh; Yun K. Choi; Christopher Kitajewski; Valeriya Borisenko; Jan Kitajewski; Carrie J. Shawber In development, lymphatic endothelial cells originate within veins and differentiate via a process requiring Prox1. Notch signaling regulates cell-fate decisions, and expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 3051–3062.
Published: 15 August 2012
... demonstrate in mice that Prox1, a transcription factor constitutively expressed in the granule cell lineage, postmitotically functions to specify DG granule cell identity. Postmitotic elimination of Prox1 caused immature DG neurons to lose the granule cell identity and in turn terminally differentiate into...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (3): 363–372.
Published: 01 February 2010
... in mice that carried a mutation in one allele of the Prox1 transcription factor ( Harvey et al., 2005 ), the activity of which is necessary and sufficient in vivo and in vitro for the specification of LEC fate ( Hong et al., 2002 ; Petrova et al., 2002 ; Wigle et al., 2002 ; Wigle and Oliver...
Journal Articles
Journal: Development
Development (2009) 136 (14): 2385–2391.
Published: 15 July 2009
... ) * These authors contributed equally to this work 12 5 2009 © 2009. 2009 Genetic modifier Sox genes Prox1 Lymphangiogenesis HLT syndrome Mouse The expression of different phenotypes caused by the same mutation is commonly attributed to genetic modifiers( Nadeau, 2001...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 495–505.
Published: 01 February 2009
... arrangement underlie congenital heart disease and cardiomyopathy. We show that cardiac-specific inactivation of the murine homeobox transcription factor Prox1 results in the disruption of expression and localisation of sarcomeric proteins, gross myofibril disarray and growth-retarded hearts. Furthermore, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (1): 29–34.
Published: 01 January 2009
... Prox1 -null mouse embryos devoid of lymph sacs and lymphatic vasculature, and in E17.5 Prox1 conditional mutant embryos, which have defective lymph sacs. However, subsequent clustering of hematopoietic cells within these developing lymph nodes is less efficient. † Authors for correspondence (e...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (12): 2115–2126.
Published: 15 June 2008
... 2008 © 2008. 2008 Zebrafish Myotome Fibre type Slow myosin heavy chain Troponin Prox1 Shh Blimp1 u-boot prdm1 Craniofacial The formation and growth of skeletal muscles in vertebrates proceeds via successive waves or phases of myogenesis that occur during embryonic and...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4243–4253.
Published: 01 December 2007
...@cchmc.org ) 11 9 2007 © 2007. 2007 Prox1 Gfi1 Otx2 Opsin Cell-specific gene expression Photoreceptor cell Drosophila photoreceptor cells (PRs) constitute a unique system for studying how neuronal diversity is achieved during sensory system development. The fly compound eye...
Journal Articles
Journal: Development
Development (2007) 134 (11): 2041–2050.
Published: 01 June 2007
... following heat-shock induction. These transgenes allow one to bypass the early embryonic requirements for Bmp and Fgf signaling, and also to completely block Bmp or Fgf signaling. We found that the expression of hhex and prox1 , the earliest liver markers in zebrafish, was severely reduced in the liver...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (6): 1343–1351.
Published: 15 March 2004
...Per-Henrik D. Edqvist; Finn Hallböök Cell migration plays an important role during the development of the retina. In this work we have studied the migration of newborn horizontal cells in avian embryonic retina. Using the pattern of the early expressed transcription factors Lim1 and Prox1 we have...