..., for their proliferation and differentiation. We previously reported that somite-derived stromal cells were a key component of the CHT niche. Here, we found that the cell adhesion protein Protocadherin 18a (Pcdh18a) is expressed in the stromal cell progenitors (SCPs) emigrating from somites toward the future CHT. Deletion...

... that the clustered protocadherin genes are differentially expressed during pancreas development. Pcdhγ genes are preferentially expressed in pancreatic endoderm, Pcdhβ genes in nascent islets, and Pcdhα genes in mature β-cells. Second, after extracting sub-networks of transcriptional regulators for each...

... of somites remains poorly understood. Here, we focused on the role of paraxial protocadherin ( PAPC/Pcdh8 ) in this process. We showed that in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM. We observed that PAPC exhibits a striking...

... - acting at least partly via the protocadherin PCDH7. Head formation Anterior mesendoderm LHX1 Transcription factor Protocadherin WNT signalling CRISPR WNT activity is important for regulating cell proliferation, differentiation and polarity ( van Amerongen and Nusse, 2009...

... of fat in the regulation of tissue polarity ( Yang et al., 2002 ), and act non-autonomously to influence the expression of Wg in the proximal wing ( Cho and Irvine, 2004 ). ds encodes a protocadherin( Clark et al., 1995 ) that appears to participate in heterophilic interactions with Fat( Ma et al...

... appears to be downstream of and required for fz function. We molecularly cloned stan and found that it encodes a huge protocadherin containing nine cadherin motifs, four EGF-like motifs, two laminin G motifs, and seven transmembrane domains. This suggests that Stan functions in signal reception, perhaps...

...Sung-Hyun Kim; Akihito Yamamoto; Tewis Bouwmeester; Eric Agius; E. M. De Robertis ABSTRACT P ar a xial P roto c adherin (PAPC) encodes a transmembrane protein expressed initially in Spemann’s organizer and then in paraxial mesoderm. Together with another member of the protocadherin family, Ax ial P...

...Akihito Yamamoto; Sharon L. Amacher; Sung-Hyun Kim; Douglas Geissert; Charles B. Kimmel; E. M. De Robertis ABSTRACT Zebrafish paraxial protocadherin ( papc ) encodes a transmembrane cell adhesion molecule (PAPC) expressed in trunk mesoderm undergoing morphogenesis. Microinjection studies...