... are required for fertility in C. elegans and contribute to repression of X-linked genes in the germline. HDAC SIN3 X chromosome C. elegans Germline Proteomics Agence Nationale de la Recherche http://dx.doi.org/10.13039/501100001665 19-CE12-0025-01 Centre National de la...

... the identification of their roles in developmental mechanisms. Proteomics Post-transcriptional regulation Protein degradation Protein synthesis Paul G. Allen Frontiers Group Chan Zuckerberg Initiative CZF2019-002424 National Institutes of Health R01GM144967...

... proteome remains elusive. In this study, Arabidopsis embryos at 2/4-cell, 8-cell, 16-cell, 32-cell, globular and heart stages were collected for nanoproteomic analysis. In total, 5386 proteins were identified. Of these, 1051 proteins were universally identified in all developmental stages and a range of 27...

... (Proteome Discoverer, v2.2). The false discovery rate (FDR) was controlled by Percolator, a semi-supervised machine learning algorithm ( Käll et al., 2007 ), using a target-decoy database strategy ( Elias and Gygi, 2010 ). Criteria for identified proteins (IPs) included a minimum of two unique corresponding...

... to nourish the developing fetus. Although advances continue in describing the molecular features regulating the differentiation of these cells, assessment of their global proteomic changes at mid-gestation remain undefined. Here, using sequential window acquisition of all theoretical fragment-ion spectra...

... and zygotic mutant for the Polycomb group gene ezh2 reveals major conserved and divergent mechanisms in epigenetic gene repression during vertebrate development. Polycomb Ezh2 Zebrafish ChIP-seq Transcriptomics Proteomics Nederlandse Organisatie voor Wetenschappelijk Onderzoek http...

...-Golgin GMAP-210 reveals that the skeletal phenotype in achondrogenesis type-1A, which is caused by mutations in GMAP-210, is solely due to impaired protein trafficking by chondrocytes. GMAP-210 Achondrogenesis type 1A Conditional knockout Golgin Cartilage Proteomics Boston Children's...

... approach with liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic methodologies to profile proteins expressed in the nuclei of developing hearts. From these studies we have identified the Xenopus orthologs of 12 human proteins encoded by genes, which when mutated in human lead to congenital...

... genetic analysis has revealed the genes involved in the specification of ventral furrow cells, few of the structural proteins that act as mediators of ventral cell behavior have been identified. A comparative proteomics approach employing difference gel electrophoresis was used to identify more than fifty...