... confirm previous findings with regards to functional specialization of some organs – the salivary gland and trachea – and clarify the embryonic functions of another – the plasmatocytes. We also identify two early developmental trajectories in germ cells and uncover a potential role for proteolysis during...

... potentially distinct functions via different receptors. Here, we report that the BMP-1/Tolloid family metalloprotease Tolkin (Tok) is responsible for Slit proteolysis in vivo and in vitro. In Drosophila tok mutants lacking Slit cleavage, midline repulsion of axons occurs normally, confirming that Slit-FL...

... upregulates phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (PTEN) expression to activate FoxO, thereby promoting proteolysis during molting in the lepidopteran insect Helicoverpa armigera . FoxO expression is increased during molting and metamorphosis. The knockdown of FoxO in fifth instar larvae...

...A. K. M. Mahbub Hasan; Aki Hashimoto; Yuka Maekawa; Takashi Matsumoto; Shota Kushima; Takashi W. Ijiri; Yasuo Fukami; Ken-ichi Sato In X enopus laevis , sperm-egg interaction promotes partial proteolysis and/or tyrosine phosphorylation of uroplakin III (UPIII) and the tyrosine kinase Src, which...

... . We show that Encore physically interacts with the proteasome, Cul1 and Cyclin E. The association of Cul1, phosphorylated Cyclin E and the proteasome 19S-RP subunit S1 with the fusome is affected in encore mutant germaria. We propose that in encore mutant germaria the proteolysis machinery is less...

... target gene wingless in embryos and that inhibition of PKA enhances induction of wingless by wild-type Ci but not by Ci5m. We therefore propose that PKA phosphorylation of Ci is required for the proteolysis of Ci-155 to Ci-75 in vivo. We also show that the activity of Ci5m remains Hedgehog responsive...

... glycoprotein proteolysis ecdysone We then asked whether gp125 could be generated in the epidermis in response to 20-HE as it is in discs. We compared dissected integuments from mid-third instar larvae (i.e. before and after the metamorphic rise of 20-HE titer in vivo) and 4 h prepupae of wild-type...

... ethanol yolk-sac function teratogenesis pinocytosis proteolysis rat embryo Excessive ingestion of ethanol, by either pregnant women or by pregnant experimental animals, is known to induce a characteristic pattern of developmental defects known as the fetal alcohol syndrome ( Abel, 1982...

... cysteine proteinases, specifically inhibited by leupeptin, are of paramount importance in this yolk sac function. 06 11 1984 Copyright © 1985 by Company of Biologists 1985 Rat embryo embryo culture cathepsins proteolysis yolk sac teratogenesis In a series of papers, Freeman...