...Elham Koosha; Connor T. A. Brenna; Amir M. Ashique; Niteesh Jain; Katie Ovens; Toshiyasu Koike; Hiroshi Kitagawa; B. Frank Eames ABSTRACT During endochondral ossification, chondrocytes secrete a proteoglycan (PG)-rich extracellular matrix that can inhibit the process of cartilage maturation...

...Noelia Escobedo; Osvaldo Contreras; Rosana Muñoz; Marjorie Farías; Héctor Carrasco; Charlotte Hill; Uyen Tran; Sophie E. Pryor; Oliver Wessely; Andrew J. Copp; Juan Larraín Syndecan 4 (Sdc4) is a cell-surface heparan sulfate proteoglycan (HSPG) that regulates gastrulation, neural tube closure...

... of the proteoglycan Dally in Hh-receiving cells in Drosophila is necessary for high but not low level pathway activity, independent of its requirement in Hh-producing cells. We demonstrate that Dally is necessary to sequester Hh at the cell surface and to promote Hh internalisation with its receptor...

... proteoglycans (CSPGs)are enriched in the growth environment of NSCs both during development and in the adult NSC niche. In order to gather insight into potential biological roles of CSPGs for NSCs, the enzyme chondroitinase ABC (ChABC) was used to selectively degrade the CSPG glycosaminoglycans. When NSCs from...

...George W. Yip; Patrizia Ferretti; Andrew J. Copp Heparan sulphate proteoglycans have been implicated in the binding and presentation of several growth factors to their receptors, thereby regulating cellular growth and differentiation. To investigate the role of heparan sulphate proteoglycans...

... cell layer. We asked whether heparan sulfate proteoglycans might regulate sonic hedgehog-induced proliferation and thereby contribute to the specialized proliferative environment of the external granule cell layer. We identified a conserved sequence within sonic hedgehog that is essential for binding...

...Theodor E. Haerry; Tim R. Heslip; J. Lawrence Marsh; Michael B. O’Connor ABSTRACT In vitro experiments suggest that glycosaminoglycans (GAGs) and the proteins to which they are attached (proteoglycans) are important for modulating growth factor signaling. However, in vivo evidence to support...

... of metanephric mesenchyme-specific factors. Interference with proteoglycan synthesis leads to loss of Wnt-11 expression in the ureter tip. We suggest that Wnt-11 acts as an autocrine factor within the ureter epithelium and that its expression is regulated at least in part by proteoglycans. Mice homozygous...

...Keiji Itoh; Sergei Y. Sokol ABSTRACT Mesoderm forms in the vertebrate embryo as a result of inductive interactions involving secreted growth factors and cell surface molecules. Proteoglycans have recently been implicated in the control of cell adhesion, migration and growth factor responsiveness...

... components (i.e. fibronectin, laminin, type IV collagen and heparan sulfate proteoglycan) found in vertebrate and more complex invertebrate species ( Sarras et al., 1991a ). Recent functional studies have demonstrated that these ECM components play an important role in hydra head regeneration ( Sarras et al...

... and protease inhibitors. A major source of this cell surface heparan sulfate is a multigene family of proteoglycans, the syndecans, that are expressed developmentally in association with changes in tissue organization and morphology and induced during wound repair. In this review, we describe mechanisms...

... transduction pathways in more detail. * Author for correspondence 08 January 1993 © 1993 by Company of Biologists 1993 extracellular matrix integrins proteoglycans signal transduction growth factors differentiation Differentiation is a continuously regulated process...

...Rita A. Hahn; David E. Birk Corneal transparency is dependent upon the development of an organized extracellular matrix containing small diameter collagen fibrils with regular spacing, organized as orthogonal lamellae. Proteoglycan-collagen interactions have been implicated in the regulation...

...Roberto Perris; Danuta Krotoski; Thomas Lallier; Carmen Domingo; J. Michael Sorrell; Marianne Bronner-Fraser In this study, we describe the distribution of various classes of proteoglycans and their potential matrix ligand, hyaluronan, during neural crest development in the trunk region...

...J. M. W. Slack; J. H. Cleine; J. C. Smith ABSTRACT This paper reviews work on the presence, synthesis and developmental regulation of glycoconjugates (proteoglycans, glycoproteins and glycolipids) in the early amphibian embryo. In the axolotl there is little regional specificity of protein...