... that Wfdc15a , a WFDC family protease inhibitor pre-programmed by KMT2B, is essential for spermatogenesis. We found that Wfdc15a is a non-canonical bivalent gene carrying both H3K4me3 and facultative H3K9me3 in SSCs, but is later activated along with the loss of H3K9me3 and acquisition of H3K27ac during...

... by the affinity with which the intestine-specific GATA-type transcription factor ELT-2 binds to promoter XXTGATAAXX sites. Transcription GATA Factor ELT-2 Binding affinity cis -acting regulatory motif C. elegans Intestine asp-1 Protease Canadian Institutes of Health Research 10.13039...

... phenotype seen in ET-3 −/− and endothelin B receptor (ET B ) −/− mice. Surprisingly, large amounts of mature ET-1 peptide are found in ECE-1 − / − embryos, indicating that non-ECE-1 protease(s) can activate ET-1 at certain sites. However, these enzymes cannot produce sufficient mature endothelin...

...Y. Sumi; M. A. R. Dent; D. E. Owen; P. J. Seeley; R. J. Morris ABSTRACT Tissue and urokinase-type plasminogen activators are serine proteases with highly restricted specificity, their best characterised role being to release the broad specificity protease plasmin from inactive plasminogen. It has...

... a soluble 90 ×10 3 M r N-terminal fragment of N-cadherin as well as a number of secreted proteases. Both of these components are also shown to be present in vivo in the vitreous humor. Northern blot analysis indicates a single mRNA encoding N-cadherin in the retina and no evidence for a second message...