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Keywords: Protamine 1 (Prm1)
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Journal Articles

Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice

Gina Esther Merges, Julia Meier, Simon Schneider, Alexander Kruse, Andreas Christian Fröbius, Gregor Kirfel, Klaus Steger, Lena Arévalo, Hubert Schorle
Journal: Development
Development (2022) 149 (12): dev200330.
https://doi.org/10.1242/dev.200330
Published: 20 June 2022
... by protamines. In humans and mice, protamine 1 ( PRM1 / Prm1 ) and protamine 2 ( PRM2 / Prm2 ) are expressed in a species-specific ratio. Using CRISPR-Cas9-mediated gene editing, we generated Prm1 -deficient mice and demonstrated that Prm1 +/− mice were subfertile, whereas Prm1 −/− mice were infertile. Prm1...
View article titled, Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice
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Includes: Supplementary data