... attributed. Summary: Macrophages are abundant in the developing mouse prostate during puberty, associating with nerve fibers and vasculature. Prostate development Macrophage Hematopoietic origin Puberty Mouse National Institutes of Health http://dx.doi.org/10.13039/100000002...

... such as prostate cancer. Analysis of the mechanistic links between development and disease could be exploited to identify signalling pathways leading to disease in the prostate. However, the mechanisms underpinning prostate development require further characterisation to interrogate fully the link between...

... that have provided new insights into androgen regulation, epithelial cell origins and cellular heterogeneity during prostate organogenesis. Prostate organogenesis Prostate development Androgen signaling Androgen receptor Cellular heterogeneity Prostate culture National Institutes...

...Adam W. Olson; Vien Le; Jinhui Wang; Alex Hiroto; Won Kyung Kim; Dong-Hoon Lee; Joseph Aldahl; Xiwei Wu; Minhyung Kim; Gerald R. Cunha; Sungyong You; Zijie Sun ABSTRACT Stromal androgen-receptor (AR) action is essential for prostate development, morphogenesis and regeneration. However, mechanisms...

...Dong-Hoon Lee; Adam W. Olson; Jinhui Wang; Won Kyung Kim; Jiaqi Mi; Hong Zeng; Vien Le; Joseph Aldahl; Alex Hiroto; Xiwei Wu; Zijie Sun ABSTRACT Androgens/androgen receptor (AR)-mediated signaling pathways are essential for prostate development, morphogenesis and regeneration. Specifically, stromal...

...Elisavet Tika; Marielle Ousset; Anne Dannau; Cédric Blanpain ABSTRACT The prostate is formed by a branched glandular epithelium composed of basal cells (BCs) and luminal cells (LCs). Multipotent and unipotent stem cells (SCs) mediate the initial steps of prostate development whereas BCs and LCs...

... of the prostatic epithelium. However, the nature of the AR-regulated morphogenetic genes and the mechanisms whereby AR controls prostate development are not understood. Glial cell line-derived neurotrophic factor (GDNF) binds GDNF family receptor α1 (GFRα1) and signals through activation of RET tyrosine kinase...

... activities by activating diverse isotypes of FGF receptor tyrosine kinases (FGFRs). Among the FGFs, FGF7 and FGF10 have been implicated in the regulation of prostate development and prostate tissue homeostasis by signaling through the FGFR2 isoform. Using conditional gene ablation with the Cre-LoxP system...

... CD44 variant isoforms. In each age group, hyaluronan was localized exclusively in the stromal matrix. Hyaluronan was greatly reduced in the later ages and was entirely absent around the developmentally quiescent proximal regions of the ducts. Early in prostate development, CD44 was prominent...