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Keywords: Prospero
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Neural development
Journal: Development
Development (2020) 147 (5): dev184085.
Published: 11 March 2020
..., and together they form the adult neuropil-glia architecture. Both lineages require the FGF receptor Heartless to proliferate, and the homeoprotein Prospero to differentiate into ALG. Lineage-specific inhibition of gliogenesis revealed that each lineage compensates for deficiency in the proliferation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (21): 3713–3720.
Published: 1 November 2015
.... Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3321–3331.
Published: 1 October 2015
... is sufficient to induce EC specification of normal progenitor cells, failed to prevent EE cell specification of Ttk69-depleted progenitors. Loss of Ttk69 led to derepression of the acheate-scute complex ( AS-C ) genes scute and asense , which then induced prospero expression to promote EE cell specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 644–653.
Published: 15 February 2015
... system. EEs can be generated from ISCs in three ways: an ISC becoming an EE, an ISC becoming a new ISC and an EE through asymmetric division, or an ISC becoming two EEs through symmetric division. We further identified that the transcriptional factor Prospero (Pros) regulates ISC commitment to EEs. Our...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4155–4164.
Published: 15 October 2013
... of the pro-differentiation transcription factor Prospero, followed by derepression of the neuroblast factors Deadpan, Asense and Cyclin E. RNA-seq shows that loss of Mdlc decreases pros transcript levels and results in aberrant pros splicing. Importantly, misexpression of the full-length human ortholog...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (14): 2639–2648.
Published: 15 July 2006
... persists into adulthood. Analysis of the expression of molecular markers, which characterize cell types in wild-type neural lineages,indicates that brat mutant clones comprise an excessive number of cells, which have molecular features of undifferentiated progenitor cells that lack nuclear Prospero (Pros...
Journal Articles
Journal: Development
Development (2006) 133 (3): 429–437.
Published: 1 February 2006
... is already expressed in the neuroblasts before this division. After mitosis, Svp protein accumulates in both cells, but the downregulation of hunchback ( hb ) occurs only in the neuroblast. In the ganglion mother cell, svp is repressed by Prospero, a transcription factor asymmetrically localised to this cell...
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (20): 4103–4112.
Published: 15 October 2001
... has been reported to be asymmetrically localized to daughter cells during precursor cell division, allowing the daughter cell to produce glia while precursor cell generates neurons. We show that (1) gcm mRNA is uniformly distributed during precursor cell divisions; (2) the Prospero transcription...
Journal Articles
Journal: Development
Development (2001) 128 (8): 1359–1367.
Published: 15 April 2001
...Zoya Demidenko; Paul Badenhorst; Tamara Jones; Xiaolin Bi; Mark A. Mortin ABSTRACT Subcellular distribution of the Prospero protein is dynamically regulated during Drosophila embryonic nervous system development. Prospero is first detected in neuroblasts where it becomes cortically localized...
Journal Articles
Journal: Development
Development (2000) 127 (16): 3513–3522.
Published: 15 August 2000
.... In this study, to understand the molecular basis for this glia-neuron cell-fate decision, we examined the effects of some known mutations on the NB6-4T lineage. First, we found that prospero (pros) mutations led to a loss of expression of Glial cells missing, which is essential to trigger glial differentiation...
Journal Articles
Journal: Development
Development (1999) 126 (20): 4617–4622.
Published: 15 October 1999
... divides to form two secondary progenitors: PIIa and PIIb. PIIb divides first to give rise to a tertiary progenitor-PIII and a glial cell. This is followed by division of PIIa to form the shaft and socket cells as described before. PIII expresses high levels of Elav and low levels of Prospero and divides...
Journal Articles
Journal: Development
Development (1999) 126 (16): 3573–3584.
Published: 15 August 1999
... along extending axons. We propose that mechanosensory organ glial cells, the origin of which was until now unknown, are generated by the asymmetric division of pIIb cells. Both Numb and Prospero segregated specifically into the basal glial and neuronal cells during the pIIb and pIIIb divisions...
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