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Keywords: Prospero
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Journal Articles
Journal: Development
Development (2020) 147 (5): dev184085.
Published: 11 March 2020
..., and together they form the adult neuropil-glia architecture. Both lineages require the FGF receptor Heartless to proliferate, and the homeoprotein Prospero to differentiate into ALG. Lineage-specific inhibition of gliogenesis revealed that each lineage compensates for deficiency in the proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (7): 1170–1181.
Published: 01 April 2016
..., only Notch is sufficient to direct non-astrocytic progenitors toward astrocytic fate. We found that Prospero is a key effector of Notch in this process. Our data identify an instructive astrogenic program that acts as a binary switch to distinguish astrocytes from other glial cells. * Author for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3713–3720.
Published: 01 November 2015
.... Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3321–3331.
Published: 01 October 2015
... Notch, which is sufficient to induce EC specification of normal progenitor cells, failed to prevent EE cell specification of Ttk69-depleted progenitors. Loss of Ttk69 led to derepression of the acheate-scute complex ( AS-C ) genes scute and asense , which then induced prospero expression to promote EE...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 644–653.
Published: 15 February 2015
... system. EEs can be generated from ISCs in three ways: an ISC becoming an EE, an ISC becoming a new ISC and an EE through asymmetric division, or an ISC becoming two EEs through symmetric division. We further identified that the transcriptional factor Prospero (Pros) regulates ISC commitment to EEs. Our...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4155–4164.
Published: 15 October 2013
... of the pro-differentiation transcription factor Prospero, followed by derepression of the neuroblast factors Deadpan, Asense and Cyclin E. RNA-seq shows that loss of Mdlc decreases pros transcript levels and results in aberrant pros splicing. Importantly, misexpression of the full-length human...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 591–600.
Published: 01 February 2007
... of signaling through the Notch(N) receptor. This is the first report showing that modulation of N signaling by Fng is important for central nervous system development in any organism. In each hemisegment of the nerve cord the transcription factor Prospero (Pros) is selectively expressed in the six...
Journal Articles
Journal: Development
Development (2006) 133 (14): 2639–2648.
Published: 15 July 2006
... persists into adulthood. Analysis of the expression of molecular markers, which characterize cell types in wild-type neural lineages,indicates that brat mutant clones comprise an excessive number of cells, which have molecular features of undifferentiated progenitor cells that lack nuclear Prospero (Pros...
Journal Articles
Journal: Development
Development (2006) 133 (3): 429–437.
Published: 01 February 2006
... already expressed in the neuroblasts before this division. After mitosis, Svp protein accumulates in both cells, but the downregulation of hunchback ( hb ) occurs only in the neuroblast. In the ganglion mother cell, svp is repressed by Prospero, a transcription factor asymmetrically localised to this cell...
Journal Articles
Journal: Development
Development (2002) 129 (2): 319–328.
Published: 15 January 2002
... dacapo p27 Cell proliferation prospero G1 arrest Drosophila Unrestrained cell proliferation results in an exponential increase of cell numbers. An accurate regulation of cell proliferation is therefore required in particular in multicellular organisms where tissue-specific limits for...
Journal Articles
Journal: Development
Development (2001) 128 (20): 4103–4112.
Published: 15 October 2001
... has been reported to be asymmetrically localized to daughter cells during precursor cell division, allowing the daughter cell to produce glia while precursor cell generates neurons. We show that (1) gcm mRNA is uniformly distributed during precursor cell divisions; (2) the Prospero transcription...