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Keywords: Proprotein convertase
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Journal Articles

Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion

Nelson J. Ramirez-Suarez, Helen M. Belalcazar, Maisha Rahman, Meera Trivedi, Leo T. H. Tang, Hannes E. Bülow
Journal: Development
Development (2023) 150 (18): dev201208.
https://doi.org/10.1242/dev.201208
Published: 18 September 2023
... molecules, which are tightly regulated to allow for coordinated neuronal outgrowth. Here, we show that the proprotein convertase KPC-1 (homolog of mammalian furin) regulates the Menorin adhesion complex during development of PVD dendritic arbors in Caenorhabditis elegans. We found a finely regulated...
View articletitled, Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion
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Includes: Supplementary data
Journal Articles

Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice

Anup Tilak, Sylvia M. Nelsen, Hyung-Seok Kim, Nathan Donley, Autumn McKnite, Hyunjung Lee, Jan L. Christian
Journal: Development
Development (2014) 141 (15): 3062–3071.
https://doi.org/10.1242/dev.110130
Published: 1 August 2014
... furin inhibitors . J. Biol. Chem. 275 , 36741 - 36749 . 10.1074/jbc.M003848200 Constam D. B. , Robertson E. J. ( 1999 ). Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases . J. Cell Biol. 144 , 139 - 149 . 10.1083/jcb.144.1.139...
View articletitled, Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice
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Includes: Supplementary data
Journal Articles

Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity

Devorah C. Goldman, Renee Hackenmiller, Takuya Nakayama, Shailaja Sopory, Crispin Wong, Holger Kulessa, Jan L. Christian
Journal: Development
Development (2006) 133 (10): 1933–1942.
https://doi.org/10.1242/dev.02368
Published: 15 May 2006
..., these studies provide the first genetic evidence that BMP4 is required for dorsal vertebral fusion and closure of the ventral body wall. Bone morphogenetic protein Proprotein convertase Proteolytic activation Embryonic patterning Cleavage mutant mouse Bone morphogenetic proteins (BMPs...
View articletitled, Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity
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