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Keywords: Proneural bHLH proteins
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Journal Articles

Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord

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Gwenvael Le Dréau, Lidia Garcia-Campmany, M. Angeles Rabadán, Tiago Ferronha, Samuel Tozer, James Briscoe, Elisa Martí
Journal: Development
Development (2012) 139 (2): 259–268.
https://doi.org/10.1242/dev.074948
Published: 15 January 2012
... of the CNS. The genetic interaction between the BMP/Smad pathway and some but not all proneural bHLH proteins could provide an underlying mechanism that explains the specificity of the effects we observed. Importantly, the role of BMP signalling in neurogenesis is independent of the early role of BMP...
View articletitled, Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord
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Includes: Supplementary data
Journal Articles

SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation

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Johan Holmberg, Emil Hansson, Michal Malewicz, Magnus Sandberg, Thomas Perlmann, Urban Lendahl, Jonas Muhr
Journal: Development
Development (2008) 135 (10): 1843–1851.
https://doi.org/10.1242/dev.020180
Published: 15 May 2008
... proteins, whereas the mechanism by which SoxB1 block neurogenesis is independent of Notch signaling. A common feature of Notch signaling and SoxB1 proteins is their ability to inhibit the activity of proneural bHLH proteins. Notch represses the transcription of proneural bHLH genes, while SoxB1 proteins...
View articletitled, SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
Open the PDF for SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation in another window
Includes: Supplementary data