... requires a careful balance between cellular proliferation and differentiation. Premature or delayed differentiation, for instance, can result in tissue imbalance, malformation or malfunction. Despite seemingly rigid constraints on development, however, there is flexibility in both the timing...

...Jie Li; Lucas P. Wachsmuth; Shiyun Xiao; Brian G. Condie; Nancy R. Manley ABSTRACT The transcription factor FOXN1 is essential for fetal thymic epithelial cell (TEC) differentiation and proliferation. Postnatally, Foxn1 levels vary widely between TEC subsets, from low/undetectable in putative TEC...

... on cardiomyocyte proliferation during postnatal development, we sought to evaluate whether Runx1 can similarly induce cardiomyocyte proliferation and myocardial regeneration in an injury context. Here, we simulated myocardial infarction (MI) by permanent ligation of the left anterior descending (LAD) artery...

...Krista M. Angileri; Nornubari A. Bagia; Cedric Feschotte ABSTRACT Tissue regeneration requires precise temporal control of cellular processes such as inflammatory signaling, chromatin remodeling and proliferation. The combination of these processes forms a unique microenvironment permissive...

... produced fewer ENCCs localized along the gut, and these ENCCs failed to reach the hindgut, resulting in HSCR-like phenotypes. Specifically, we observed a proliferation-dependent migration mechanism, where cell divisions were associated with inter-cell distances and migration speed. Lastly, we detected...

... of proliferation versus differentiation in the central nervous system . Cell Tissue Res. 359 , 187 - 200 . 10.1007/s00441-014-1895-8 Jang , J. , Han , D. , Golkaram , M. , Audouard , M. , Liu , G. , Bridges , D. , Hellander , S. , Chialastri , A. , Dey , S. S...

...André Rosa; Wolfgang Giese; Katja Meier; Silvanus Alt; Alexandra Klaus-Bergmann; Lowell T. Edgar; Eireen Bartels-Klein; Russell T. Collins; Anna Szymborska; Baptiste Coxam; Miguel O. Bernabeu; Holger Gerhardt ABSTRACT Endothelial cell migration and proliferation are essential for the establishment...

.... ( 2006 ). Mitf regulation of Dia1 controls melanoma proliferation and invasiveness . Genes Dev. 20 , 3426 - 3439 . 10.1101/gad.406406 Chi , G. F. , Kim , D. W. , Jiang , M. H. , Yoon , K. J. and Son , Y. ( 2011 ). Schwann-like cells from human melanocytes...

...Hessel Honkoop; Phong D. Nguyen; Veronique E. M. van der Velden; Katharina F. Sonnen; Jeroen Bakkers ABSTRACT Zebrafish are excellent at regenerating their heart by reinitiating proliferation in pre-existing cardiomyocytes. Studying how zebrafish achieve this holds great potential in developing new...

.... In contrast, cartilage overgrowth and scoliosis are absent in rare viable nkx3.2 knockdown animals that lack jaw joints, supporting post-embryonic roles for Nkx3.2. Single-cell RNA-sequencing and in vivo validation reveal increased proliferation and upregulation of stress-induced pathways, including...

.... Highlighted Article: In the Drosophila wing, the Argonaute family protein AGO1 acts independently of the miRNA-silencing pathway to restrict tissue growth by directly repressing transcription of the master growth regulator Myc. Argonaute Drosophila Myc Proliferation Psi Transcription...

...Zhen Shi; Cindy Lim; Vuong Tran; Kairong Cui; Keji Zhao; Xin Chen ABSTRACT The Drosophila male germline stem cell (GSC) lineage provides a great model to understand stem cell maintenance, proliferation, differentiation and dedifferentiation. Here, we use the Drosophila GSC lineage to systematically...

... generation by negatively regulating oligodendrocyte precursor cell (OPC) proliferation. GDE3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRα, the ligand-binding component of the CNTF-receptor multiprotein complex, which can function...

...Raz Ben-Yair; Vincent L. Butty; Michele Busby; Yutong Qiu; Stuart S. Levine; Alon Goren; Laurie A. Boyer; C. Geoffrey Burns; Caroline E. Burns ABSTRACT Deciphering the genetic and epigenetic regulation of cardiomyocyte proliferation in organisms that are capable of robust cardiac renewal...

... levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration...

... is essential for cardiomyocyte proliferation and cardiogenesis. Mosaic Myc overexpression in a Mycn -deficient background shows that Myc can replace Mycn function, recovering heart development. We further show that this recovery involves the elimination of Mycn-deficient cells by cell competition. Our results...

... and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates. During regenerative responses, surviving cells and their descendants often change their cell fate or identity to reconstruct the missing tissue/appendage. Imaginal...

.... Here, we study how increased cell number evolved in the vertebrate central nervous system, investigating the regulation of cell proliferation in the lamprey spinal cord. Markers of proliferation show that a ventricular progenitor zone is found throughout the lamprey spinal cord. We show that inhibition...

... that Cdc42 is required for endothelial tip cell selection, directed cell migration and filopodia formation, but dispensable for cell proliferation or apoptosis. Although the loss of Cdc42 seems generally compatible with apical-basal polarization and lumen formation in retinal blood vessels, it leads...

..., proliferation and survival of glial precursors. Both the switch from neurogenesis to gliogenesis and the subsequent glial expansion depend on Notch signaling. Taken together, lineage origins preconfigure the development of individual glial precursors with involvement of serial Notch actions in promoting...