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Keywords: Proliferation
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Journal Articles
Journal: Development
Development (2021) 148 (2): dev193409.
Published: 25 January 2021
.... In contrast, cartilage overgrowth and scoliosis are absent in rare viable nkx3.2 knockdown animals that lack jaw joints, supporting post-embryonic roles for Nkx3.2. Single-cell RNA-sequencing and in vivo validation reveal increased proliferation and upregulation of stress-induced pathways, including...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev190231.
Published: 11 June 2020
... Myc Proliferation Psi Transcription Tightly coordinated regulation of cell and tissue growth is essential for animal development. Decreased growth leads to small organs and diminished body size, whereas heightened proliferative growth is associated with genomic instability and cancer. The...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184259.
Published: 12 April 2020
...Zhen Shi; Cindy Lim; Vuong Tran; Kairong Cui; Keji Zhao; Xin Chen ABSTRACT The Drosophila male germline stem cell (GSC) lineage provides a great model to understand stem cell maintenance, proliferation, differentiation and dedifferentiation. Here, we use the Drosophila GSC lineage to systematically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev180695.
Published: 23 January 2020
... generation by negatively regulating oligodendrocyte precursor cell (OPC) proliferation. GDE3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRα, the ligand-binding component of the CNTF-receptor multiprotein complex, which can function as...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev178632.
Published: 09 October 2019
...Raz Ben-Yair; Vincent L. Butty; Michele Busby; Yutong Qiu; Stuart S. Levine; Alon Goren; Laurie A. Boyer; C. Geoffrey Burns; Caroline E. Burns ABSTRACT Deciphering the genetic and epigenetic regulation of cardiomyocyte proliferation in organisms that are capable of robust cardiac renewal, such as...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev178087.
Published: 09 May 2019
... levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev170753.
Published: 01 February 2019
... is essential for cardiomyocyte proliferation and cardiogenesis. Mosaic Myc overexpression in a Mycn -deficient background shows that Myc can replace Mycn function, recovering heart development. We further show that this recovery involves the elimination of Mycn-deficient cells by cell competition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates. Competing interests The authors declare no competing or financial interests. 10 9 2018 3 12 2018 © 2019. Published by The Company of...
Journal Articles
Journal: Development
Development (2019) 146 (1): dev166595.
Published: 09 January 2019
... spinal cord. Here, we study how increased cell number evolved in the vertebrate central nervous system, investigating the regulation of cell proliferation in the lamprey spinal cord. Markers of proliferation show that a ventricular progenitor zone is found throughout the lamprey spinal cord. We show that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev161182.
Published: 02 July 2018
... Cdc42 is required for endothelial tip cell selection, directed cell migration and filopodia formation, but dispensable for cell proliferation or apoptosis. Although the loss of Cdc42 seems generally compatible with apical-basal polarization and lumen formation in retinal blood vessels, it leads to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev160127.
Published: 11 June 2018
..., proliferation and survival of glial precursors. Both the switch from neurogenesis to gliogenesis and the subsequent glial expansion depend on Notch signaling. Taken together, lineage origins preconfigure the development of individual glial precursors with involvement of serial Notch actions in promoting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4406–4421.
Published: 01 December 2017
... hormone 20-hydroxyecdysone (20E) in the maintenance of numerous patterning systems in vivo and in explant culture. We find that low concentrations of 20E support prolonged proliferation in explanted wing discs in the absence of insulin, incidentally providing novel insight into the hormonal regulation of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4462–4472.
Published: 01 December 2017
... tissue movements during elongation. We quantify the tissue-specific contribution to axis elongation using 3D volumetric techniques, then quantify tissue-specific parameters such as cell density and proliferation. To study cell behavior at a multi-tissue scale, we used high-resolution 4D imaging of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 479–486.
Published: 01 February 2017
... cell-cell sorting analyses. However, we demonstrate that only the earlier autopod cells can adopt the host proliferation rate to permit normal morphogenesis. Therefore, our findings reveal that the ability of embryonic cells to differentially reset their intrinsic behaviours confers robustness to limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4509–4520.
Published: 01 December 2016
...Gewei Lian; Markus Dettenhofer; Jie Lu; Michael Downing; Anjen Chenn; Timothy Wong; Volney Sheen Actin-associated proteins regulate multiple cellular processes, including proliferation and differentiation, but the molecular mechanisms underlying these processes are unclear. Here, we report that the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2398–2409.
Published: 01 July 2016
... liver. However, its role in the brain remains unclear. Here, we provide evidence for YAP regulation of mouse neocortical astrocytic differentiation and proliferation. YAP was undetectable in neurons, but selectively expressed in neural stem cells (NSCs) and astrocytes. YAP in NSCs was required for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1388–1399.
Published: 15 April 2016
... control proliferation. Furthermore, spectrin mutant cells show differentiation and polarity defects only in the ectopic layers of stratified epithelia, similar to integrin mutants. Our results identify α-Spectrin and integrins as novel regulators of apical constriction-independent cell elongation, as α...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 729–740.
Published: 01 March 2016
... basis of this ineffective cardiac regeneration in mammals is the low proliferative capacity of adult cardiomyocytes. However, mammalian cardiomyocytes can avidly proliferate during fetal and neonatal development, and both adult zebrafish and neonatal mice can regenerate cardiac muscle after injury...
Journal Articles
Journal: Development
Development (2015) 142 (24): 4230–4241.
Published: 15 December 2015
...Patrick Narbonne; Paul S. Maddox; Jean-Claude Labbé During development, stem cell populations rapidly proliferate to populate the expanding tissues and organs. During this phase, nutrient status, by systemically affecting insulin/IGF-1 signalling, largely dictates stem cell proliferation rates. In...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4340–4350.
Published: 15 December 2015
... the cardiac cushions. The transcription factor SOX9 is highly expressed in the cardiac cushion mesenchyme, and is essential for heart valve development. Loss of Sox9 in mouse cardiac cushion mesenchyme alters cell proliferation, embryonic survival, and valve formation. Despite this important role...
Includes: Supplementary data