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Keywords: Progenitor cells
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Journal Articles
Journal: Development
Development (2019) 146 (23): dev178855.
Published: 04 December 2019
... such as the esophagus. However, the molecular mechanisms regulating these progenitor activities in the esophagus remain to be elucidated. Here, we demonstrated that Yap is required for the proliferation of esophageal progenitor cells (EPCs) in the developing murine esophagus. We found that Yap deficiency reduces EPC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev176735.
Published: 22 July 2019
... territories change from territories that function as an expanding pool of progenitor cells to territories in which there is an equal level of non-boundary proliferative activity and neurogenic capacity. We consider that the different observations in chick and zebrafish can be explained by the different...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev175810.
Published: 01 May 2019
... , M. A. , Polo , J. M. , Bronson , R. , Sengupta , S. , Seandel , M. , Geijsen , N. and Hochedlinger , K. ( 2011 ). Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice . Cell Stem Cell   9 , 317 - 329 . 10.1016/j.stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4608–4619.
Published: 15 December 2016
...Jacqueline L. Norrie; Qiang Li; Swanie Co; Bau-Lin Huang; Ding Ding; Jann C. Uy; Zhicheng Ji; Susan Mackem; Mark T. Bedford; Antonella Galli; Hongkai Ji; Steven A. Vokes During embryonic development, undifferentiated progenitor cells balance the generation of additional progenitor cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (7): 1099–1107.
Published: 01 April 2016
..., has not yet been achieved for continuously growing adult tissues, but is essential if we wish to understand the architecture of adult organs. The retinas of lower vertebrates grow throughout life from retinal stem cells (RSCs) and retinal progenitor cells (RPCs) at the rim of the retina, called...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3239–3251.
Published: 15 September 2015
.... Luminal progenitor cells of two out of three donors gave rise to branched structures, suggesting that plasticity can occur in this compartment. Future studies will address whether plasticity in the luminal compartment reflects normal regeneration or a process of illicit dedifferentiation, as was suggested...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1028–1042.
Published: 15 March 2015
... of expansion and proliferation. The mammary gland thus provides an excellent model for studying the ‘stem/progenitorcells that allow this repeated expansion and renewal. In this Review, we provide an overview of the different cell types that constitute the mammary gland, and discuss how these cell types...
Journal Articles
Journal: Development
Development (2015) 142 (2): 258–267.
Published: 15 January 2015
... for homeostasis and repair of the conducting airways. Little is known about how these progenitor cells expand and transition to differentiation to form the pseudostratified airway epithelium in the developing and adult lung. Here, we show by genetic and pharmacological approaches that endogenous activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1589–1598.
Published: 01 April 2014
... ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Clonal lineage CRE recombinase piggyBac transposase Multi-fluorescence Progenitor cells Fate mapping...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4522–4532.
Published: 15 November 2013
... of fetal cells (fetal cortex derived Gli1 -expressing cells and mesenchymal Tcf21 -expressing mesenchymal cells) participate in the establishment of the homeostatic capsular progenitor cell niche of the adult cortex. ‡ Author for correspondence ( ghammer@umich.edu ) * Present address: Magee...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 740–750.
Published: 15 February 2013
... expressed in early retinal progenitor cells and that Sox4 expression began around birth, when expression of Sox11 subsided. To analyze the roles of Sox11 and Sox4 in retinal development, we perturbed their expression patterns in retinal explant cultures. Overexpression of Sox11 and Sox4 in retinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 3921–3930.
Published: 15 September 2011
... of the trunk. The NMs are deposited by a migrating pLL primordium, which is organized into polarized rosettes (proto-NMs). During migration, mature proto-NMs are deposited from the trailing part of the primordium, while progenitor cells in the leading part give rise to new proto-NMs. Wnt signaling is active...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 1893–1902.
Published: 15 May 2011
... approach defines a number of cadherin genes that may play a role in cell patterning, proliferation and differentiation within the developing spinal cord. Of these, we have studied one, FatJ, in detail. FatJ is localised to progenitor cells within intermediate regions along the dorsoventral axis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1247–1257.
Published: 01 April 2011
... complete organ failure to congenital hypertension. A balance between differentiation and maintenance of a mesenchymal progenitor cell population determines the final number of nephrons. How this balance is struck is poorly understood. Previous studies have suggested that Wnt9b/β-catenin signaling induced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1395–1407.
Published: 01 April 2011
... progenitor cell identity at the expense of differentiated cell phenotypes, we test whether genetic activation of Notch could rescue the Eya1 −/− lung phenotype, which is characterized by loss of epithelial progenitors, increased epithelial differentiation but reduced branching. Indeed, genetic activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (22): 3741–3745.
Published: 15 November 2009
...-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am. J. Respir. Cell Mol. Biol. 24 , 671 -681. Jen, Y., Manova, K. and Benezra, R. ( 1996 ). Expression patterns of Id1, Id2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (1): 127–136.
Published: 01 January 2007
... function of fezl has been previously proposed for their development. However, recent evidence favors the hypothesis that fezl is expressed in the dopaminergic progenitor cells to cell autonomously control their development( Jeong et al., 2006 ). Several lines of evidence suggest that fezl may also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (12): 2759–2770.
Published: 15 June 2005
...Fumi Kubo; Masatoshi Takeichi; Shinichi Nakagawa During the development of the central nervous system, cell proliferation and differentiation are precisely regulated. In the vertebrate eye, progenitor cells located in the marginal-most region of the neural retina continue to proliferate for a much...
Journal Articles
Journal: Development
Development (2005) 132 (6): 1363–1374.
Published: 15 March 2005
...Tadashi Okubo; Paul S. Knoepfler; Robert N. Eisenman; Brigid L. M. Hogan Understanding how lung progenitor cells balance proliferation against differentiation is relevant to clinical disorders such as bronchopulmonary dysplasia of premature babies and lung cancer . Previous studies have established...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (20): 4843–4853.
Published: 15 October 2002
... asymmetric cell divisions and consequently diverse neural cell fates. We investigated whether a mouse homologue m-numb had a similar role during mouse cortical development. Progenitor cells isolated from the embryonic mouse cortex were followed as they underwent their next cell division in vitro. Numb...