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Keywords: Progenitor cell
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Journal Articles
Journal: Development
Development (2020) 147 (12): dev178582.
Published: 22 June 2020
... to arise from a common thymic epithelial progenitor cell (TEPC). However, the mechanisms controlling cTEC and mTEC production from the common TEPC are not understood. Here, we show that emergence of the earliest mTEC lineage-restricted progenitors requires active NOTCH signaling in progenitor TEC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev176974.
Published: 8 May 2019
... of Biologists Ltd 2019 Summary: Research reported at the seventh EMBO meeting on the Molecular and Cellular Basis of Regeneration and Tissue Repair included important discoveries on regeneration and provided perspectives for regenerative medicine. Cell plasticity Progenitor cell Regeneration...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev165381.
Published: 18 December 2018
... of a specialized pool of progenitor cells that express both SRY-box 9 ( Sox9 ), a key regulator of chondrogenesis, and the tendon marker scleraxis ( Scx ) ( Akiyama et al., 2005 ; Blitz et al., 2013 ; Schweitzer et al., 2001 ; Sugimoto et al., 2013 ). Cell lineage studies have shown that Sox9 -expressing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev160184.
Published: 17 May 2018
... in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial progenitor cells remains limited. The assumption that most murine embryonic lymphatic endothelial cells (LECs) are venous derived has recently been challenged. Here, we show that the embryonic dermal blood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 211–220.
Published: 15 January 2017
... + progenitor cells in the endbuds of reconstituted glands. Addition of exogenous endothelial cells to reconstituted glands restored epithelial patterning, as did supplementation with the endothelial cell-regulated mesenchymal factors IGFBP2 and IGFBP3. Our results demonstrate that endothelial cells promote...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1831–1839.
Published: 15 May 2015
... embedded within the quadriceps tendon. At the cellular level, we show that, similar to bone eminences, the patella is formed secondarily by a distinct pool of Sox9 - and Scx -positive progenitor cells. Finally, we show that TGFβ signaling is necessary for the specification of patella progenitors, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 117–125.
Published: 1 January 2013
... days. Glands were collected and fixed 4 hours after the final treatment. PTP1B (Ptpn1) Stat5 Mammary gland Stem cell Progenitor cell Mouse The epithelium of rodent and human mammary glands is hierarchically organized, encompassing cells at various differentiation stages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2187–2197.
Published: 1 July 2009
... taste papillae. FST limits expansion and differentiation of Sox2 -expressing taste progenitor cells and negatively regulates the development of taste papillae in the lingual epithelium: in Fst -/- tongue, there is both ectopic development of Sox2 -expressing taste progenitors and accelerated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (13): 2289–2299.
Published: 1 July 2008
...Michael J. McGrew; Adrian Sherman; Simon G. Lillico; Fiona M. Ellard; Pippa A. Radcliffe; Hazel J. Gilhooley; Kyriacos A. Mitrophanous; Noemí Cambray; Valerie Wilson; Helen Sang The outgrowth of the vertebrate tail is thought to involve the proliferation of regionalised stem/progenitor cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (1): 145–157.
Published: 1 January 2008
... NG2 (CSPG4) Oligodendrocyte Progenitor cell Astrocyte Myelin Transgene FACS Glial cells in the mammalian central nervous system (CNS) that express the NG2 proteoglycan [also known as chrondroitin sulfate proteoglycan 4 (CSPG4) -Mouse Genome Informatics; NG2 glia] begin to appear during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (6): 1231–1242.
Published: 15 March 2007
...Ricardo C. Moraes; Xiaomei Zhang; Nikesha Harrington; Jennifer Y. Fung; Meng-Fen Wu; Susan G. Hilsenbeck; D. Craig Allred; Michael T. Lewis The hedgehog signaling network regulates pattern formation, proliferation,cell fate and stem/progenitor cell self-renewal in many organs. Altered hedgehog...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 3027–3037.
Published: 1 August 2006
...Joanne G. W. Nijhof; Kristin M. Braun; Adam Giangreco; Carina van Pelt; Hiroshi Kawamoto; Richard L. Boyd; Rein Willemze; Leon H. F. Mullenders; Fiona M. Watt; Frank R. de Gruijl; Willem van Ewijk We describe a novel murine progenitor cell population localised to a previously uncharacterised region...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2639–2648.
Published: 15 July 2006
... persists into adulthood. Analysis of the expression of molecular markers, which characterize cell types in wild-type neural lineages,indicates that brat mutant clones comprise an excessive number of cells, which have molecular features of undifferentiated progenitor cells that lack nuclear Prospero (Pros...
Journal Articles
Journal: Development
Development (2005) 132 (2): 267–277.
Published: 15 January 2005
...Jérôme Teulière; Marisa M. Faraldo; Marie-Ange Deugnier; Michael Shtutman; Avri Ben-Ze'ev; Jean Paul Thiery; Marina A. Glukhova Wnt/β-catenin signaling pathway is involved in the maintenance of the progenitor cell population in the skin, intestine and other tissues, and its aberrant activation...
Journal Articles
Journal: Development
Development (2003) 130 (2): 391–399.
Published: 15 January 2003
... from the pool of proliferating progenitor cells and lead to a lasting effect of adult neurogenesis. * Author for correspondence (e-mail: gerd.kempermann@mdc-berlin.de ) 11 10 2002 © 2003. 2003 Stem cell Progenitor cell Adult neurogenesis Mouse In adult hippocampal...
Journal Articles
Journal: Development
Development (2002) 129 (16): 3873–3885.
Published: 15 August 2002
... of a self-renewing population of progenitor cells that are the primary source of cells driving the growth and morphogenesis of the myotome and dermomyotome in the epaxial domain of the body. Previous work showed that the DML of somites from ssVIII to XV was both necessary and sufficient to provide...