... ID1 is enriched in mouse basal epidermal progenitor cells and find ID1 expression to be diminished upon differentiation. In utero silencing of Id1 impairs progenitor cell proliferation, leads to precocious delamination of targeted progenitor cells and enables differentiated keratinocytes to retain...

... Murakami ABSTRACT Periodontal tissue supports teeth in the alveolar bone socket via fibrous attachment of the periodontal ligament (PDL). The PDL contains periodontal fibroblasts and stem/progenitor cells, collectively known as PDL cells (PDLCs), on top of osteoblasts and cementoblasts on the surface...

... to arise from a common thymic epithelial progenitor cell (TEPC). However, the mechanisms controlling cTEC and mTEC production from the common TEPC are not understood. Here, we show that emergence of the earliest mTEC lineage-restricted progenitors requires active NOTCH signaling in progenitor TEC...

... of Biologists Ltd 2019 Summary: Research reported at the seventh EMBO meeting on the Molecular and Cellular Basis of Regeneration and Tissue Repair included important discoveries on regeneration and provided perspectives for regenerative medicine. Cell plasticity Progenitor cell Regeneration...

... population establishes a simple embryonic tissue, whereas another population is responsible for its postnatal maturation into a complex structure. Musculoskeletal development Enthesis Sox9 Gli1 Progenitor cell Hedgehog signaling R26R - Confetti Mouse National Institutes of Health...

... in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial progenitor cells remains limited. The assumption that most murine embryonic lymphatic endothelial cells (LECs) are venous derived has recently been challenged. Here, we show that the embryonic dermal blood...

... + progenitor cells in the endbuds of reconstituted glands. Addition of exogenous endothelial cells to reconstituted glands restored epithelial patterning, as did supplementation with the endothelial cell-regulated mesenchymal factors IGFBP2 and IGFBP3. Our results demonstrate that endothelial cells promote...

... embedded within the quadriceps tendon. At the cellular level, we show that, similar to bone eminences, the patella is formed secondarily by a distinct pool of Sox9 - and Scx -positive progenitor cells. Finally, we show that TGFβ signaling is necessary for the specification of patella progenitors, whereas...

... and the number of colonies quantified. Ptp1b –/– MECs formed approximately twice as many colonies as Ptp1b +/+ MECs, which suggested an increase in progenitor cells in glands lacking PTP1B ( Fig. 2B ). Furthermore, the colonies formed by Ptp1b –/– MECs were larger ( Fig. 2B ), consistent with our...

... taste papillae. FST limits expansion and differentiation of Sox2 -expressing taste progenitor cells and negatively regulates the development of taste papillae in the lingual epithelium: in Fst -/- tongue, there is both ectopic development of Sox2 -expressing taste progenitors and accelerated...

...Michael J. McGrew; Adrian Sherman; Simon G. Lillico; Fiona M. Ellard; Pippa A. Radcliffe; Hazel J. Gilhooley; Kyriacos A. Mitrophanous; Noemí Cambray; Valerie Wilson; Helen Sang The outgrowth of the vertebrate tail is thought to involve the proliferation of regionalised stem/progenitor cell...

... NG2 (CSPG4) Oligodendrocyte Progenitor cell Astrocyte Myelin Transgene FACS Glial cells in the mammalian central nervous system (CNS) that express the NG2 proteoglycan [also known as chrondroitin sulfate proteoglycan 4 (CSPG4) -Mouse Genome Informatics; NG2 glia] begin to appear during...

...Ricardo C. Moraes; Xiaomei Zhang; Nikesha Harrington; Jennifer Y. Fung; Meng-Fen Wu; Susan G. Hilsenbeck; D. Craig Allred; Michael T. Lewis The hedgehog signaling network regulates pattern formation, proliferation,cell fate and stem/progenitor cell self-renewal in many organs. Altered hedgehog...

...Joanne G. W. Nijhof; Kristin M. Braun; Adam Giangreco; Carina van Pelt; Hiroshi Kawamoto; Richard L. Boyd; Rein Willemze; Leon H. F. Mullenders; Fiona M. Watt; Frank R. de Gruijl; Willem van Ewijk We describe a novel murine progenitor cell population localised to a previously uncharacterised region...

... persists into adulthood. Analysis of the expression of molecular markers, which characterize cell types in wild-type neural lineages,indicates that brat mutant clones comprise an excessive number of cells, which have molecular features of undifferentiated progenitor cells that lack nuclear Prospero (Pros...

...Jérôme Teulière; Marisa M. Faraldo; Marie-Ange Deugnier; Michael Shtutman; Avri Ben-Ze'ev; Jean Paul Thiery; Marina A. Glukhova Wnt/β-catenin signaling pathway is involved in the maintenance of the progenitor cell population in the skin, intestine and other tissues, and its aberrant activation...

... from the pool of proliferating progenitor cells and lead to a lasting effect of adult neurogenesis. References Altman, J. and Bayer, S. A. ( 1990 ). Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells. J. Comp. Neurol. 301 , 325...

... of a self-renewing population of progenitor cells that are the primary source of cells driving the growth and morphogenesis of the myotome and dermomyotome in the epaxial domain of the body. The few BrdU-labelled myotome cells that appear during a 2 hour pulse-chase are scattered randomly throughout...

... is expressed in several types of migratory progenitor cells in the embryo including cranial neural crest cells, lung smooth muscle progenitors and oligodendrocyte progenitors. To study PDGFR α gene regulation and function during development, we generated transgenic mice by pronuclear injection of a 380 kb...

... acquired distinct functions during evolution. * Author for correspondence (e-mail: [email protected] ) 05 08 1999 09 06 1999 © 1999 by Company of Biologists 1999 Lateral inhibition Stem cell Progenitor cell Transgenic mice Nervous system The Notch...